T cell Maturation

Question 1

Name cytokines released by TH1

Answer 1

Il-2 and IFN-gamma

Question 2

Purpose of Il-4 and IL-13 released by TH2

Answer 2

Activate M2 macrophages

Question 3

Name the surface markers on Tcyt (CTL)

Answer 3

CD8+
CD95L (fas-L)
CD3+

Question 4

Treg releases these cytokines to suppress helper T cells

Answer 4

TGF-beta

Il-10

Question 5

Il-4 stimulates and is realeased by this T helper cell

Answer 5

TH2

Question 6

Disorder cause by DR2 HLA mutation

Answer 6

Narcolepsy

Question 7

These 2 HLA mutations can cause type II diabetes

Answer 7

DR3

DR4

Question 8

Explain why somatic hypermutation does not occur in T-cell receptors

Answer 8

Because there is no regulation once the cells leave the thymus so hypermutation could be detrimental

Question 9

Name the co-stimulatory molecules on the MHC - TCR connection

Answer 9

LFA-3 (binds CD2)

B7 (binds CD28) B7-1 and B7-2 equivalent to CD80 and CD86

Question 10

What molecule on the TCR binds to ICAM-1

Answer 10

LFA-1 (integrin - leukocyte fucntional antigen)

Question 11

Activator of M1 macrophages

Answer 11

IFN-gamma

Question 12

Unique surface marker on Tfh

Answer 12

CXCR-5

Question 13

Name all the possible gene combinations for MHC Class II

Answer 13

DP alphaM betaM
DP alphaM betaF
DP alphaF betaM
DP alphaFbetaF
DQ
DR

Question 14

CD4+, CD25, CD127 and CD3+ are all markers on this cell

Answer 14

Treg

Question 15

TH17 cytokines that attract/activate inflammatory cells

Answer 15

IL-17

IL-22