anemia

Question 1

Define WAHA

Answer 1

warm autoimmune hemolytic anemia

Question 2

WAHA pearls

Answer 2

IgG
Spleen
Spherocytes

Question 3

Define CAHA

Answer 3

cold autoimmunei hemolytic anemia

Question 4

CAHA pearls

Answer 4

IgM, complement
Intravascular hemolysis
Agglutination

Question 5

Clinical Signs of CAHA

Answer 5

Chronic hemolysis aggravated by cold

Pallor/cyanosis in cold body parts

Question 6

What are Hemoglobinopathies?

Answer 6

Structurally abnormal hemoglobin - most important one is sickle cell anemis

Question 7

Describe sickle beta chains

Answer 7

valine where a glutamate should be

Question 8

Treatment of sickle crisis

Answer 8

Blood transfusion, BMT

Question 9

Problems in Beta-thalassemia

Answer 9

defective transcription, translation, or mRNA processing of beta-chain

Question 10

Thalassemia can look like this disorder

Answer 10

iron def. anemia

hypochromic, microcytic amnemia

Question 11

Heinz body anemia refers to this

Answer 11

G6PD def.

Question 12

Cause of Microangiopathic Hemolytic Anemis

Answer 12

Physical trauma to cells

Question 13

Hallmark of Microangiopathic hemolytic anemia

Answer 13

triangulocyte

Question 14

ACOD pearls

Answer 14

Infections, Inflammation, Malignancy
Iron metabolism disturbed
Mormochromic, normocytic
Usually mild

Question 15

Anemia of Renal Disease Pearls

Answer 15

End stage renal failure
Lack of EPO
Echinocytes

Question 16

Anemia of Liver Disease Pearls

Answer 16

Multiple causes, usually complicated

Acanthocytes

Question 17

Aplastic Anemia disease Pearls

Answer 17

Pancytopenia
Empty marrow
Most are idiopathic

Question 18

None idipathic causes of Aplastic anemia

Answer 18

Drugs
Viruses
Pregnancy
Fanconi anemia

Question 19

For what anemias may you see spheroctyes?

Answer 19

WAHA, CAHA

Question 20

Name the abnormal shape anemias

Answer 20

G6PD
Microangiopathic Hemolytic Anemia
Thallasemia
Hemoglobinoptahies
Anemia of Renal Disease
Anemia of LIver Disease

Question 21

List some cause for Normocytic, normal shape RBC anemia

Answer 21

AOCD
Aplastic Anemia
Anemia of blood loss

Question 22

How would you treat WAHA?

Answer 22

Steroids and splenectomy

Question 23

Definitive diagnostic tool for distinguishing Hemoglobinapthies and Thallasemia

Answer 23

Hemoglobin Electrophoresis

Question 24

Some aplastic anemia

Answer 24

Blood
G-CSF, Prednisone, AGD (immunosupprant)
Last resort - BMT