Therapeutic Drug Monitoring (Chemistry) Flashcards
Blood specimens for digoxin assays should be obtained between 8 hrs or more after drug administration because:
A) tissue and serum levels need to reach equilibrium
B) serum digoxin concentration will be falsely low prior to 6 hrs
C) all of the digoxin is in the ceullular fraction prior to 6 hrs
D) digoxin protein-binding interactions are minimal prior to 6 hrs
A) tissue and serum levels need to reach equilibrium
A drug has a half-life of 6 hours. If a dose is given every 6 hours, a steady-state drug level would usually be achieved in:
A) 3-5 hrs
B) 10-12 hrs
C) 24-42 hrs
D) 48-50 hrs
C) 24-42 hrs
Free therapeutic drug levels are usually higher when serum protein concentrations are below normal. In which of the following conditions would this most likely occur?
A) acute inflammation
B) nephrotic syndrome
C) pregnancy
D) multiple myeloma
B) nephrotic syndrome
Which of these following factors is not relevant to therapeutic drug monitoring (TDM) of the aminoglycosides, antibiotics and vanomycin?
A) intestinal absorption
B) nephrotoxicity
C) ototoxicity
D) renal function
A) intestinal absorption
The drug procainamide is prescribed to treat cardiac arrhythmia. What biologically active liver metabolite of procainamide is often measured simultaneously?
A) phenobarbitol
B) quinidine
C) N-acetyl procainamide (NAPA)
D) lidocaine
C) N-acetyl procainamide (NAPA)
A carbonate salt used to control manic-depressive disorders is:
A) digoxin
B) acetaminophen
C) lithium
D) phenytoin
C) lithium
An antiepileptic (or anticonvulsant) used to control seizure disorders is:
A) digoxin
B) acetaminophen
C) lithium
D) phenytoin
D) phenytoin
A drug that relaxes the smooth muscles of the bronchial passages is:
A) acetaminophen
B) lithium
C) phenytoin
D) theophylline
D) theophylline
A cardiac glycoside that is used in the treatment of congenital heart failure and arrhythmias by increasing the force and velocity of mocardial contraction is:
A) digoxin
B) acetaminophen
C) lithium
D) phenytoin
A) digoxin
lithium therapy is widely used in the treatment of:
A) hypertension
B) hyperactivity
C) aggression
D) manic-depressive (bipolar) disorder
D) manic-depressive (bipolar) disorder
An active metabolite of amitriptylin is:
A) nortriptyline
B) protriptyline
C) butriptyline
D) norbytriptyline
A) nortriptyline
Phenobarbital is a metabolite of:
A) primidone
B) phenytoin
C) amobarbital
D) secobarbital
A) primidone
Reverse phase high-performing liquid chromatography is being increasingly utilized in therapeutic drug monitoring. The term reverse phase implies that the column eluant is:
A) pumped up the column
B) more polar than the stationary phase
C) always nonpolar
D) less polar than the stationary phase
B) more polar than the stationary phase
