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Cyp450 Interactions > Therapeutic antibodies > Flashcards

Therapeutic antibodies Flashcards

1
Q

what is the target for alemtuzumab? what is it used for?

A
  • CD52

- CLL

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2
Q

what is the target for bevacizumab? what is it used for?

A
  • VEGF

- colorectal cancer, RCC

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3
Q

what is the target for cetuximab? what is it used for?

A
  • EGFR

- stage IV colorectal, head and neck cancer

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4
Q

what is the target for rituximab? what is it used for?

A
  • CD20

- B cell non-Hodgkin, CLL, RA, ITP

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5
Q

what is the target for trastuzumab? what is it used for?

A
  • HER2 / neu

- breast cancer

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6
Q

what is the target for adalimumab? what is it used for?

A
  • soluble TNFa

- IBD, RA, akylosing spon, psoriasis

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7
Q

what is the target for eculizumab? what is it used for?

A
  • C5

- PNH

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8
Q

what is the target for natalizumab? what is it used for?

A
  • a4 integrin

- MS, crohn

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9
Q

what is the target for abciximab? what is it used for?

A
  • platelet gpIIb / IIIa

- prevention of ischemic complications in PCI

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10
Q

what is the target for denosumab? what is it used for?

A
  • RANKL

- osteoporosis, inhibits osteoclast maturation

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11
Q

what is the target for omalizumab? what is it used for?

A
  • IgE

- allergic asthma, prevents IgE binding to FceRI

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12
Q

what is the target for palivizumab? what is it used for?

A
  • RSV F protein

- RSV prophylaxis for high risk infants

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13
Q

what is the target for ranibizumab?

A
  • VEGF

- neovascular age related macular degeneration

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14
Q

CD52

A

alemtuzumab

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15
Q

VEGF

A
  • bevacizumab

- ranibizumab

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16
Q

EGFR

A

cetuximab

17
Q

CD20

A

rituximab

18
Q

HER2/neu

A

trastuzumab

19
Q

soluble TNFa

A
  • adalimumab

- infliximab

20
Q

C5

A

eculizumab

21
Q

a4 integrin

A

natalizumab

22
Q

gp IIb/IIIa

A

abciximab

23
Q

RANKL

A

denosumab

24
Q

IgE

A

omalizumab

25
Q

RSH F protein

A

palivizumab

Cyp450 Interactions (18 decks)

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