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Cyp450 Interactions > Rate determining enzymes of metabolic processes > Flashcards

Rate determining enzymes of metabolic processes Flashcards

1
Q

glycolysis

A

PFK-1

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2
Q

gluconeogenesis

A

F-1,6-BP

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3
Q

TCA cycle

A

isocitrate DH

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4
Q

glycogenesis

A

glycogen synthase

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5
Q

glycogenolysis

A

glycogen phosphorylase

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6
Q

HMP shunt

A

G6PD

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7
Q

de novo pyrimidine synthesis

A

CPS 2

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8
Q

de novo purine synthesis

A

glutamine PRPP amidotransferase

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9
Q

urea cycle

A

CPS 1

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10
Q

fatty acid synthesis

A

acetyl-CoA carboxylase

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11
Q

fatty acid oxidation

A

carnitine acyltransferase I (CAT I)

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12
Q

ketogenesis

A

HMG CoA SYNTHASE

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13
Q

cholesterol synthesis

A

HMG CoA reductase

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14
Q

what is/are the positive regulator(s) of gluconeogenesis ?

A
  • ATP

- acetyl CoA

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15
Q

what is/are the positive regulator(s) of the TCA cycle?

A

ADP

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16
Q

what is/are the positive regulator(s) of glycogenesis?

A
  • G6P
  • insulin
  • cortisol
17
Q

what is/are the positive regulator(s) of glycogenolysis?

A
  • EPI
  • glucagon
  • AMP
18
Q

what is/are the positive regulator(s) of the HMP shunt?

19
Q

what is/are the positive regulator(s) of de novo pyrimidine synthesis?

20
Q

what is/are the positive regulator(s) of the urea cycle?

A

N-acetylglutamate

21
Q

what is/are the positive regulator(s) of fatty acid synthesis?

A
  • insulin

- citrate

22
Q

what is/are the positive regulator(s) of cholesterol synthesis?

A
  • insulin

- thyroxine

Cyp450 Interactions (18 decks)

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