Antimicrobials Flashcards by Daniel Coquyt

Q

what is the MOA of fluoroquinolones?

A

inhibit DNA topoisomerase II (gyrase) and IV

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Q

what is the MOA of metronidazole?

A

damages DNA

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Q

what is the MOA of rifampin?

A

inhibits mRNA synthesis (RNA pol)

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Q

what is the MOA of the macrolides?

A

inhibits 50S subunit

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Q

what is the MOA of chloramphenicol?

A

inhibits 50S subunit

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Q

what is the MOA of clindamycin?

A

inhibits 50S subunit

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Q

what is the MOA of linezolid?

A

inhibits 50S subunit

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Q

what is the MOA of aminioglycosides?

A

inhibit 30S subunit

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Q

what is the MOA of tetracyclines?

A

inhibit 30S subunit

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Q

what is the MOA of penicilillnase-sensitive penicillins?

A

inhibit pep glycan cross linking

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Q

what is the MOA of penicillinase-resistant penicillins?

A

inhibit pep glycan cross linking

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Q

what is the MOA of antipseudomonals?

A

inhibit pep glycan cross linking

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Q

what is the MOA of cephs?

A

inhibits pep glycan cross linking

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Q

what is the MOA of carbapenems?

A

inhibit pep glycan cross linking

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Q

what is the MOA of monobactams?

A

inhibit pep glycan cross linking

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Q

what is the MOA of glycopeptides?

A

inhibit pep glycan SYNTHESIS

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Q

what are the glycopeptides?

A

bacitracin

- vancomycin

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Q

what is the MOA of the sulfonamides?

A

inhibit folic acid synthesis

Q

what is the MOA of INH?

A

inhibits mycolic acid synthesis

Q

what is the MOA of ethambutol?

A

inhibits arabinoglycan synthesis (arabinosyl transferase)

Q

what is the MOA of rifabutin?

A

inhibits mRNA synthesis (DNA dependent RNA pol)

Q

what is the MOA of terbinafine?

A

inhibits lanosterol synthesis

Q

what is the MOA of the echinocandins?

A

inhibits fungal cell wall synthesis

Q

what is the MOA of the polyenes?

A

form membrane pores

Q

what is the MOA of flycytosine?

A

inhibits nucleic acid synthesis

Q

what is the MOA of the azoles?

A

inhibit ergosterol synthesis

Q

what is the MOA of maraviroc?

A

inhibits HIV fusion / ATTACHMENT

Q

what is the MOA of enfuvirtide?

A

inhibits HIV fusion / PENETRATION

Q

abacavir is a(n) ________________

A

NRTI

Q

efavirenz is a(n) ________________

A

NNRTI

Q

lamivudine is a(n) ________________

A

NRTI

Q

tenofovir is a(n) ________________

A

NRTI

Q

zidovudine is a(n) ________________

A

NRTI

Q

nevirapine is a(n) ________________

A

NNRTI

Q

didanosine is is a(n) ________________

A

NRTI

Q

emtricitabine is a(n) ________________

A

NRTI

Q

what is the MOA of IFNa?

A

inhibits protein synthesis

Q

what is the MOA of amantadine and rimantadine?

A

inhibit viral uncoating

Q

what are the guanosine analogs?

A

acyclovir

- gancyclovir

Q

what are the viral DNA pol inhibitors?

A

cidofovir

- foscarnet

Q

what is the MOA of ribavirin?

A

guanine nucleotide synthesis inhibitor

Q

what is the MOA of oseltamivir?

A

neuraminidase inhibitor

Q

what is the MOA of zanamivir?

A

neuraminidase inhibitor