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Pharm > Therapeutic Antibodies > Flashcards

Therapeutic Antibodies Flashcards

0
Q

Bevacizumab

A

Targets VEGF

Used in colorectal cancer, RCC

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1
Q

Alemtuzumab

A

Targets CD52

Used in CLL

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2
Q

Cetuximab

A

Blocks EGFR

Used in stage IV colorectal cancer, head and neck cancer

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3
Q

Rituximab

A

Against CD20

B cell Hodgkin lymphoma, ITP, RA

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4
Q

Trastuzumab

A

Against HER2/neu

Breast cancer and gastric cancer

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5
Q

Infliximab and adalinumab

A

Against TNF-a

PAIR

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6
Q

Natalizumab

A

Against a4-integrin (leukocyte adhesion)
MS and chrons
Risk of PML in patients with JC virus

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7
Q

Abciximab

A

GpIIb/IIIa

Platelet aggregation for percutaneous coronary intervention

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8
Q

Denosumab

A

Against RANKL

Inhibits osteoclasts maturation (mimics osteoprotegrin)

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9
Q

Omalizumab

A

Against IgE

Allergic asthma, prevents FceRI binding

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10
Q

Palivizumab

A

Against RSV F protein

RSV prophylaxis for high-risk infants

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Pharm (12 decks)

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