Psych

Question 0

Trifluoperazine

Answer 0

High potency typical antipsychotic
Blocks dopamine D2 receptors
EPS side effects (treat benztropine or diphenhydramine)

Question 1

Haloperidol

Answer 1

High potency typical antipsychotic
Blocks dopamine D2 receptors
EPS side effects (treat benztropine or diphenhydramine)

Question 2

Fluphenazine

Answer 2

High potency typical antipsychotic
Blocks dopamine D2 receptors
EPS side effects (treat benztropine or diphenhydramine)

Question 3

Chlorpromazine

Answer 3

Low potency typical antipsychotic
Blocks dopamine D2 receptors
Anticholinergic, antihistamine, a1 blockade side effects
Corneal deposits

Question 4

Thioridazine

Answer 4

Low potency typical antipsychotic
Blocks dopamine D2 receptors
Anticholinergic, antihistamine, a1 blockade side effects
Retinal deposits

Question 5

Olanzapine

Answer 5

Atypical antipsychotic

Weight gain

Question 6

Clozapine

Answer 6

Atypical antipsychotic
Agranulocytosis- check CBC weekly
Weight gain
Acts on D4 receptors

Question 7

Quetiapine

Answer 7

Atypical antipsychotic

Question 8

Risperidone

Answer 8

Atypical antipsychotic

Prolactin increase- menstruation problems

Question 9

Aripiprazole

Answer 9

Atypical antipsychotic

Question 10

Ziprasidone

Answer 10

Atypical antipsychotic

Prolong qt interval

Question 11

Lithium

Answer 11

May inhibit phosphoinositol pathway
Mood stabilizer for bipolar also SIADH
Tremor, Nephrogenic DI (and accumulate), hypothyroid (weight gain, hair loss, consto), fetal defects (Epstein anomaly and great vessel malformation)
Narrow therapeutic window

Question 12

Buspirone

Answer 12

Stimulated 5-HT1A receptors
Generalized anxiety disorder
No interaction w etoh (unlike benzos and barbs)

Question 13

Fluoxetine

Answer 13

SSRI
Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
Takes 4-8 weeks to work
Sex dysfunction
Serotonin syndrome (treat cyproheptadine)

Question 14

Paroxetine

Answer 14

SSRI
Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
Takes 4-8 weeks to work
Sex dysfunction
Serotonin syndrome (treat cyproheptadine)

Question 15

Sertraline

Answer 15

SSRI
Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
Takes 4-8 weeks to work
Sex dysfunction
Serotonin syndrome (treat cyproheptadine)

Question 16

Citalopram

Answer 16

SSRI
Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
Takes 4-8 weeks to work
Sex dysfunction
Serotonin syndrome (treat cyproheptadine)

Question 17

Venlafaxine

Answer 17

SNRI- serotonin and norepinephrine
Depression
GAD and panic disorders
Increased BP

Question 18

Duloxetine

Answer 18

SNRI- serotonin and norepinephrine
Depression
Also for Peripheral diabetic neuropathy
Increased BP

Question 19

Amytriptyline

Answer 19

TCA
Block serotonin and norepinephrine reuptake
Major depression
3* TCA more anticholinergic effects- tachy, dry mouth, urinary retention
Convulsion coma cardiotoxicity (3 Cs)
Prolonged qrs and qt
Confusion in elderly, use nortriptyline

Question 20

Nortriptyline

Answer 20

TCA
Block serotonin and norepinephrine reuptake
Major depression, fibromyalgia
2* TCA
Convulsion coma cardiotoxicity (3 Cs)
Prolonged qrs and qt
Confusion in elderly, use nortriptyline

Question 21

-pramine

Answer 21

TCA
Block serotonin and norepinephrine reuptake
Major depression fibromyalgia
Convulsion coma cardiotoxicity (3 Cs)
Prolonged qrs and qt
Confusion in elderly, use nortriptyline
Clomipramine for OCD
Desipramine can cause seizures

Question 22

Tranylcypromine

Answer 22

Mao-I
Increased amine NTs (NE, serotonin, dopamine)
Atypical depression, anxiety, hypochondriasis
Hypertensive crisis when eat tyramine
Cns stimulation
Contraindicated w ssri, TCA, St. John wart, meperidine, dextromethorophan because of serotonin syndrome

Question 23

Phenelzine

Answer 23

Mao-I
Increased amine NTs (NE, serotonin, dopamine)
Atypical depression, anxiety, hypochondriasis
Hypertensive crisis when eat tyramine
Cns stimulation
Contraindicated w ssri, TCA, St. John wart, meperidine, dextromethorophan because of serotonin syndrome

Question 24

Isocarboxazid

Answer 24

Mao-I Increased amine NTs (NE, serotonin, dopamine) Atypical depression, anxiety, hypochondriasis Hypertensive crisis when eat tyramine Cns stimulation Contraindicated w ssri, TCA, St. John wart, meperidine, dextromethorophan because of serotonin syndrome

Question 25

Segeline

Answer 25

Mao-I selective MAO B Increased amine NTs (NE, serotonin, dopamine) Atypical depression, anxiety, hypochondriasis Hypertensive crisis when eat tyramine Cns stimulation Contraindicated w ssri, TCA, St. John wart, meperidine, dextromethorophan because of serotonin syndrome

Question 26

Bupropion

Answer 26

``` Atypical antidepressant Increase NE and dopa Also used for smoking cessation Seizure in bulimic patients No sexual side effects ```

Question 27

Mirtazipine

Answer 27

a2 antagonist (release NE and serotonin) Potent 5-HT2 and 5-HT3 receptor antagonist Sedation, weight gain, dry mouth

Question 28

Trazodone

Answer 28

Blocks 5-HT2 and a1- adrenergic receptors Mostly used for insomnia Priapism and nausea