GI Flashcards by Colin Tasi

Q

Ranitidine

A

Reversible block of H2 receptors
Peptic ulcer, mild gerd
Decreases creatinine excretion (as does cimetidine)

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Q

Cimetidine

A

Reversible block of H2 receptors
Peptic ulcer, mild gerd
Potent inhibitor of p450
Antiandrogenic effects
Can cross BBB and placenta
Decreases creatinine excretion (as does ranitidine)

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Q

Famotidine

A

Reversible block of H2 receptors
Peptic ulcer, mild gerd
Fewer side effects than cimetidine and ranitidine

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Q

Nizatidine

A

Reversible block of H2 receptors
Peptic ulcer, mild gerd
Fewer side effects than cimetidine and ranitidine

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Q

Omeprazole

A

IRREVERSIBLY inhibit H/K ATPase
Peptic ulcer, GERD, ZES
Risk of c diff, pneumonia
Hip fractures and low mg w long term use

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Q

Lansoprazole

A

IRREVERSIBLY inhibit H/K ATPase
Peptic ulcer, GERD, ZES
Risk of c diff, pneumonia
Hip fractures and low mg w long term use

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Q

Esomeprazole

A

IRREVERSIBLY inhibit H/K ATPase
Peptic ulcer, GERD, ZES
Risk of c diff, pneumonia
Hip fractures and low mg w long term use

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Q

Pantoprazole

A

IRREVERSIBLY inhibit H/K ATPase
Peptic ulcer, GERD, ZES
Risk of c diff, pneumonia
Hip fractures and low mg w long term use

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Q

Dexlansoprazole

A

IRREVERSIBLY inhibit H/K ATPase
Peptic ulcer, GERD, ZES
Risk of c diff, pneumonia
Hip fractures and low mg w long term use

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Q

Bismuth, sucralfate

A

Bind to ulcer base, allow hco3- to reestablish ph

Faster ulcer healing, travelers diarrhea

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Q

Misoprostol

A

PGE1 analog
Increases gastric mucosa barrier secretion, decreases acid
Prevent NSAID induced ulcers
Induce labor, maintain PDA
Abortificant

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Q

Ocreotide

A

Long acting somatostatin analog

Acute variceal bleeds, acromegaly, VIPoma, carcinoid tumors

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Q

Aluminum hydroxide

A

Can cause:
Constipation
Hypophosphatemia
Prox muscle weakness
Osteodystrophy
Seizures

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Q

Calcium carbonate

A

Can cause:
hypercalcemia
Rebound acid increase
Can chelate other drugs (tetracycline)

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Q

Magnesium hydroxide

A

Can cause:
Diarrhea
Hyporeflexia
Hypotension
Cardiac arrest

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Q

Magnesium citrate

A

Osmotic laxative

Q

Polyethylene glycol

A

Osmotic laxative

Q

Lactulose

A

Osmotic laxative

Also can treat hepatic encephalopathy- gut flora break it to lactic and acetic acid, promotes nitrogen excretion as NH4+

Q

Infliximab

A

Monoclonal antibody to TNF-a
Chron, UC, RA, ank spon, psoriasis
Can lead to infection and TB reactivation

Q

Sulfasalazine

A

Sulfapyridine (antibacterial) and 5-aminosalicylic acid (anti-inflammatory)
Activated by colonic bacteria
UC, chrons
Can cause reversible oligospermia

Q

Ondansetron

A

5-HT3 antagonist
Decreases Vagal stim
Central acting antiemetic
Think in chemo

Q

Metroclopramide

A

D2 receptor antagonist
Increase LES and resting tone, motility. No effect on transport time
Antiemetic, gastroparesis
Can get parkinsonian effects. Don’t give if have Parkinson’s (D1 blockade), or small bowel obstruction