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Pharm > Immunosuppressants > Flashcards

Immunosuppressants Flashcards

0
Q

Tacrolimus

A

Calcineurin inhibitor
Binds FK506 binding protein (FKBP)
Prevents IL-2 transcription
Nephrotoxic, no hirsutism or gingival hyperplasia

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1
Q

Cyclosporine

A

Calcineurin inhibitor
Binds cyclophilin, prevents IL-2 transcription
Nephrotoxic
Hirsutism, gingival hyperplasia

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2
Q

Sirolimus

A 
Mtor inhibitor
Binds FKBP (FK605 binding protein)
Blocks T cell and B cell activation
Prevents IL-2 SIGNAL TRANSDUCTION
not nephrotoxic
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3
Q

Basiliximab

A

Monoclonal antibody to IL-2 receptor

Edema, tremor

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4
Q

Azathioprine

A

Turns into 6-MP
Inhibits lymphocyte proliferation by blocking nucleotide synthesis (purines)
Broken down by xanthine oxidase (allopurinol

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5
Q

Glucocorticoids

A

Inhibits NF-kB

Depresses B and T cell function by decreasing cytokine transcription

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Pharm (12 decks)

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