Neuro

Question 0

Benzos (seizures)

Answer 0

Status epilepticus
Increases GABAa action
Anterograde amnesia

Question 1

Ethosuxamide

Answer 1

Blocks thalamic T-type Ca channels
Absence seizures
E CAUSES FGHIJ
fatigue, GI, HA, itching, Johnson syndrome

Question 2

Carbamazepine

Answer 2

Na+ channel inactivation
Simple, complex, TC
Agranulocytosis and aplastic anemia, blood days raises, liver tox, teratogenesis, 450 induction, SJS
First line trigeminal neuralgia

Question 3

Phenytoin

Answer 3

Na+ channel inactivation
SE prophylaxis, TC
Zero order kinetics
Diplopia, gingival hyperplasia, hirsutism, peripheral neuropathy, fetal hydantoin syndrome, SJS, megaloblastic anemia, 450 induction, lymphadenopathy

Question 4

Valproic acid

Answer 4

Na+ channel inactivation
Increase GABA conc by inhibiting GABA transaminase
First line TC, most else in non preg
Neural tube defects, weight gain
Rare fatal hepatotoxicities
Also bipolar and myoclonic seizures

Question 5

Gabapentin

Answer 5

Inhibits high-voltage activated Ca++ channels, GABA analogue

Also post hermetic neuralgia, migraine proph, bipolar disorder

Question 6

Phenobarbital

Answer 6

Increases GABAa

First line neonates

Question 7

Topiromate

Answer 7

Blocks Na+ channels
Increases GABA
Also migraine prevention
Mental dulling and kidney stones

Question 8

Lamotragine

Answer 8

Everything but status epilepticus
Blocks voltage gated Na channels
SJS if don’t titration slowly

Question 9

Tigabine

Answer 9

Blocks GABA reuptake

Simple/complex focal

Question 10

Vigabatrin

Answer 10

Increases GABA by irreversibly inhibiting GABA transaminase

Simple/complex focal

Question 11

Phenobarbital

Answer 11

Barbiturate

Increase GABA action by increasing cl channel open duration

Question 12

Thiopental

Answer 12

Barbiturate

Cl Channel duration

Question 13

Triazolam

Answer 13

Short acting benzo (cl channel frequency)

Question 14

Oxazepam

Answer 14

Short acting benzo (cl channel frequency)

Question 15

Midazolam

Answer 15

Short acting benzo (cl channel frequency)

Question 16

Temazepam

Answer 16

Long acting benzo (cl channel frequency)

Question 17

Chlordiazepoxide

Answer 17

Long acting benzo (cl channel frequency)

Question 18

Zaleplon

Answer 18

BZ1 subtype GABA receptor. Better sleep than benzos

Question 19

Eszopicline

Answer 19

BZ1 subtype GABA receptor. Better sleep than benzos

Question 20

Halothane

Answer 20

Inhaled anesthetic
Hepatotoxic
Malignant hyperthermia w succinylcholine (hereditary)

Question 21

Methoxyflurane

Answer 21

Inhaled anesthetic
Nephrotoxic
Malignant hyperthermia w succinylcholine (hereditary)

Question 22

Enflurane

Answer 22

Inhaled anesthetic
Proconvulsant
Malignant hyperthermia w succinylcholine (hereditary)

Question 23

Dantroline

Answer 23

Prevents release of Ca++ from sarcoplasmic reticulum

Treat malignant hyperthermia and neuroleptic malignant syndrome

Question 24

Parkinson drugs

Answer 24

B- bromocryptine (ergot dopa agonist)
L- levo/carbidopa
A- amantadine (dopa release, also infA and rubella)
B- benztropine- antimuscarinic
S- selegiline- selective maoB inhib, blocks just dopa breakdown, not norepi or serotonin

Question 25

Memantine

Answer 25

NMDA receptor antagonist

Prevents Ca mediated excitotoxicity with ach boosting Alzheimer’s drugs

Question 26

Rivastigmine and..

Answer 26

Ache inhib

Alzheimer’s

Question 27

Tetrabenazine

Answer 27

Inhibit vesicular mao transporter

Less dopamine release

Question 28

Reserpine

Answer 28

Inhibit vesicular mao transporter
Less dopamine release
For huntingtons

Question 29

Haloperidol

Answer 29

Dopamine receptor antagonist

For huntingtons