THE THIRD MIDTERM Flashcards
What are three common symptoms of breast diseases?
- Pain
- Palpable Masses
- Nipple Discharge
Why don’t we screen women for breast cancer until age 40?
• Start screening at ~40 yrs because younger women have denser breast tissue making it difficult to identify a mass
What does mammography help with?
- It detects density
- Can show architectural distortions
- Identifies calcification
- Changes over time and these changes can indication pathologies such as cancers
- Can use imaging to help guide biopsy needle in order to sample a growth.
What percent of breast cancers can’t be detected through mammography?
~10% of breast cancers that are not detected by mammography, can be detected by palpitation
What are the characteristics of acute mastitis?
- Can cause breast abscesses and necrosis
- Typically associated with women who are breast feeding.
- Can be caused by plugged ducts
- Can be infectious or non-infectious
What is fat necrosis of the breast usually associated with?
• Usually associated with trauma (from a seat belt during an accident)
What are the characteristics of breast cysts?
- Fibrolytic changes
- Higher risk of breast cancer
- Occurs 20-40 years old
- Doesn’t typically occur after menopause
- Can calcify
- Can look like cancer on mammogram
What are the characteristics of benign neoplasms of the breast?
- Fibroadenomas are the most common
- Mostly connective tissue
- Well circumscribed
- Don’t typically remove unless uncomfortable.
What are the breast carcinoma statistics?
- Rarely occurs
- ~30% incidence by 70 yrs of age
- No racial influence, but there is environmental influences
- Inherited=5-10% (BRCA 1 and 2 the most common inherited genes)
~250,000 new breast cancers in U.S./yr.
What are the symptoms of breast carcinoma?
- Pain
- Masses (assessed by palpitation, mammography, ultrasound, MRI, or tissue biopsied)
What is the prognosis of breast carcinoma?
- Based on size, axillary node status, and distant metastasis
- 5 year Survival rate of stage 0 (early stage)=92%, stage IV (late)= 13%
- If tumor expresses estrogen/progesterone receptors, it often responds to hormonal treatment
What are the types of breast carcinoma?
- Invasive carcinoma: 75-85%
- Most are ductal and the incidence increases with age and have invasive and non-invasive types
- Can do lumpectomies to remove smaller masses.
What are benign epithelial lesions?
Benign epithelial lesions
-typically fibrocytic changes (e.g.,60% of women have microscopic cysts associated with epithelial tissue.
What is the main type of cervical cancer and what are the risk factors?
- HPV (human papillomavirus)- associated squamous cell neoplasm represents most cervical cancers -use pap smear to detect early
- Risk factors -multiple sex partners -Immunosuppression -early age of first sexual contact -oral contraception for >5 years -nicotine use
What are the three main causes of polyps in the endometrium?
- Hypertension
- Obesity
- Late menopause
What are the risks and treatment associated with endometrial cancer (adenocarcinoma)?
- Risks • Obesity • Diabetes • Hypertension
- Treatment • Hysterectomy-treatment of choice • Radiation/chemotherapy adjunctive
What is the main cause of endometritis?
IUDs
What is endometrial hyperplasia and what are the treatments?
- Exaggerated responses due to excessive estrogen (e.g., excessive ovarian activity), that can progress to cancer.
- Treatment: Progesterone, Hysterectomy
What are the two main types of ovarian masses?
- Non-neoplastic cysts (e.g., follicular)
- Neoplastic: e.g., endometroioid
- Most are sporadic
- Contraceptives can decrease risk
- Treatment: -total hysterectomy + removal of surrounding tissue + chemotherapy
What are the symptoms of ovarian masses? When is the screening recommended for ovarian cancer?
- Pelvic pain
- Pelvic mass
- Abdominal bleeding
Unlike cervical cancer, there is no effective screening for ovarian cancer
How do estrogens and progestins work as hormone replacement therapy options?
Estrogens and Progestins
- Natural estrogens are steroid hormones—synthesized estrogens may be non-steroidal
- They cross cell membranes and activate estrogen receptors inside cell—modulate expression of genes
What are the names of the three stages of the menstrual cycle?
The menstrual cycle:
- Menstrual stage—menses
- Follicular stage—proliferative
- Luteal stage—secretory
As populations age, they spend less time in menopause (females) or andropause (males). True or False?
False, they spend more time.
What are the names of the three natural estrogens? And at what stage of life are these predominant?
- Estrone (predominant during menopause)- E1
- Estradiol (predominant during productive years)—E2
- Estratriol (predominant during pregnancy)—E3