Quiz 5 Flashcards
What is osteoarthritis?
a. Loss of articular cartilage with secondary changes in bone
b. Presents in some degree in most persons >65 years of age. Symptoms worsen with excessive use.
c. Due to wear and tear
d. No inflammatory changes
What are the types of breast carcinoma?
- Invasive carcinoma: 75-85%
- Most are ductal and the incidence increases with age and have invasive and non-invasive types
- Can do lumpectomies to remove smaller masses.
What is endometrial hyperplasia and what are the treatments?
- Exaggerated responses due to excessive estrogen (e.g., excessive ovarian activity), that can progress to cancer.
- Treatment: Progesterone, Hysterectomy
What does mammography help with?
- It detects density
- Can show architectural distortions
- Identifies calcification
- Changes over time and these changes can indication pathologies such as cancers
- Can use imaging to help guide biopsy needle in order to sample a growth.
What is osteogenesis imperfecta?
- Osteogenesis imperfecta
a. Deficient or defective type 1 collagen—too little bone
b. Generalized osteopenia
- Multiple fractures and bone deformities
- Malformed teeth (dentin deficiency)
What are the three main causes of polyps in the endometrium?
- Hypertension
- Obesity
- Late menopause
What are the three expressions of acne?
- Opened comodones (blackheads)
- Closed comodones (white heads)
- Cysts, pustules and abscesses
Dantrolene
- An anti-spasmotic that is used as a muscle relaxant. is a postsynaptic muscle relaxant that lessen excitation-contraction coupling in muscle cells by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors.
- It is the primary drug used for the treatment and prevention of malignant hyperthermia, a rare, life-threatening disorder triggered by general anesthesia.
- Its direct effect is peripheral only.
What types of diseases or conditions can chronic inflammation lead to?
- Cancers
- Pulmonary diseases
- Cardiovascular diseases
- Diabetes
- Alzheimer’s disease
- Oral diseases (periodontal tissues)
- Neurological disease
- Arthritis
What are the different types of delivery forms for contraceptives?
• Combinations:
- • Monophasics- constant doses of both estrogen and progesterone
- • Biphasic- dosage of one or both change one time during cycle
- • Triphasic-dosages change 2 times
- Progestin only—referred to as the “minipill” (no estrogen); fewer side effects, but less effective
- Implantable
- Injections (i.m., sustained effects)
- Intravaginal rings
- IUDs with and without estrogen/progestin
- Transdermal combinations
Tetracyclines
Antibiotics for Acne Vulgaris. Minocycline is more lipophilic (may accumulate in sebaceous gland).
- Chelated by dairy products, calcium, and magnesium so passes though gut without absorbtion with wrong foods/drinks.
- has higher incidence of inner ear disturbances with associated dizziness, ataxia, vertigo and Tinnitus (especially in women), and is more expensive than doxycycline.
- Doxycycline may be associated with more GI upset than minocycline.
– Harder to chelate thus beNer absorbed with food.
– All tetracycline antibiotics are associated with increased risk of irritable bowel syndrome.
– If tetracyclines aren’t tolerated or effective, then 3rd line opDon is trimethaprim or trimethaprim-sulfamethoxazole (TMP-SMZ). - Category D pregnancy Risk
What are the risks and treatment associated with endometrial cancer (adenocarcinoma)?
- Risks • Obesity • Diabetes • Hypertension
- Treatment • Hysterectomy-treatment of choice • Radiation/chemotherapy adjunctive
What are the four main physiologic effects of progestins?
- Increase fat deposition
- Decrease CNS excitability (e.g., antiseizure—opposite of estrogen)
- Increase aldosterone—increase Na+ retention—increase BP—increase water retention and blood volume
- Increase body temperature
What are the three types of therapeutic groups for muscle relaxants?
- Spasmolytics (reduce spasticity by modifying the stretch reflex arc and/ or interfering directly with excitation-contraction coupling of the skeletal muscles. (Diazepam, Baclofen, Tizanidine, Dantrolene)
- Non-depolarizing blocking (produce muscle paralysis by either nondepolarizing blockade (d-tubocurarine))
- Depolarizing blocking (paradoxical depolarizing blockade (desensitization) (succinylcholine) of the ganglionic nicotinic ACh receptor)
What are the characteristics of perioral dermatitis?
- Young women
- Long-term steroid use or cosmetic use
- Follicular papules, vesicles and pustules
What is osteomyelitis and what are the five things that can cause it?
Osteomyelitis (inflammation of bone/marrow)
a. blood-born or direct
b. trauma from compound fractures
c. pyogenic infections (e.g., staph aureus or salmonella)
d. granulomatous (TB or fungal)- called “Pott disease” when associated with TB
e. Diabetes—due to poor circulation in the extremities-if chronic can form a drainage site and can even become osteosarcoma
What is the main type of cervical cancer and what are the risk factors?
- HPV (human papillomavirus)- associated squamous cell neoplasm represents most cervical cancers -use pap smear to detect early
- Risk factors -multiple sex partners -Immunosuppression -early age of first sexual contact -oral contraception for >5 years -nicotine use
How are non-depolarizing blockers reversed?
Non-depolarizing blockers are reversed by acetylcholinesterase (AChE) inhibitors, since they are competitive antagonists at the ACh receptor.
D-tubocurarine
Is a non-depolarizing neuromuscular blocker. Blocks ganglionic nicotinic receptor.
What are progestins made from, other characteristics, hal-life, etc?
- Made from cholesterol
- Present in males, but less than females
a. Progesterone (natural)—most important progestin in human • Precursor to estrogen, androgen and adrenalcortical steroids (e.g., cortisol)
• Also precursor to testosterone and estradiol c. Half life= 5 min. (very short acting)
What is the main cause of endometritis?
IUDs
Clomiphene
Clomifene or clomiphene is a selective estrogen receptor modulator that has become the most widely prescribed drug for ovulation induction to reverse anovulation or oligoovulation. Ovulation-inducing; for promoting fertilization and pregnancy (increased risk of multiple births—e.g., twins). Clomed.
What is fat necrosis of the breast usually associated with?
• Usually associated with trauma (from a seat belt during an accident)
What are the characteristics of NSAIDS?
- Decrease pain and inflammation
- Cox I (GI, bleeding and kidney side effects) and Cox II (MI and stroke and hypertension side effects) inhibitors
- Aspirin, ibuprofen, naproxen are non-selective COX I and II inhibitors
- Celecoxib is COX II inhibiton
Side Effects
- (a) CNS-tinnitis
- (b) CVS-hypertension
- (c) GI-nausea, ulcers or bleeding
- (d) Hepatic-altered liver functions
- (e) Pulmonary-asthma
- (f) Skin-rashes
- (g) Renal- insufficiency, in extreme can have failure