The Pap Smear, Cervical Dysplasia, and Cancer Flashcards

1
Q

Where do most of the neoplasias arise in the cervix?

A

-the SCJ

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2
Q

Which HPV types cause the majority of cancers?

A

-16, 18, 31, 45

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3
Q

Which HPV typse are associated with genital warts and with low grade lesions?

A

-6 and 11

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4
Q

If girls are under 21, should they get a pap smear?

A

-No!

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5
Q

how often should women 21-29 get paps?

A

-cytology alone every 3 years

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6
Q

women 30-65 paps?

A

-HPV and cytology cotesting every 5 years

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7
Q

If a woman is >65 and there is an adequate negative prior screening, does she need screening anymore?

A

-no

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8
Q

do women need a screening after hysterectomy?

A

-no

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9
Q

What is the system that interprets the pap smear?

A

-the Bethesda system

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10
Q

If a woman has atypical squamous cells of undetermined significance on cytology, what do we do?

A
  • either repeat cytology or do HPV testing (preferred)
  • if there’s something wrong, then do colposcopy
  • if HPV negative, repeat every 3 yrs
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11
Q

if HPV is present, what do we do?

A
  • colposcopy

- if LSIL with negative HPV test, then repeat cotesting @ 1 year

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12
Q

What can we do if a woman has HSIL?

A
  • immediate loop electrosurgical excision

- or colposcopy (with endocervical assessment)

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13
Q

What is considered the gold standard for diagnosis and treatment planning for cervix stuff?

A

-colposcopy

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14
Q

What is colposcopy?

A
  • -binocular stereomicroscope with variable magnification

- cervix washes with 3% acetic acid… dehydrates cells and large nuclei of abnormal cells turn white

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15
Q

What are the white abnormal cells on colposcopy called?

A

-Acetowhite changes

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16
Q

What kind of changes are we looking for at the SC junction on colposcopy?

A
  • acetowhite changes
  • punctuations
  • mosaicism
  • abnormal vessels
  • masses
17
Q

If there is a little yellowish bump on the cervix, what is that?

A
  • nabothian cyst

- completely normal

18
Q

If there is a woman who is found to have a high risk HPV and she wants the HPV vaccine, what do we tell her?

A

-kindly fuck off because you’re not getting it

19
Q

What are the 2 ablative tx options?

A
  • cryotherapy

- laser ablation

20
Q

What are the two excisional tx options?

A
  • cold knife cone (CKC)

- Loop electrode excisional procedure (LEEP)

21
Q

When are excisional techniques done?

A
  • when endocervical cureettage positive (need CKC)
  • unsatisfactory colposcopy (no SCJ)
  • substantial discrepancy between pap and biopsy
22
Q

What kind of cancers are cervical cancers most of the time?

A

-squamous cell carcinomas

23
Q

What are some symptoms of cervical cancer?

A
  • water vaginal bleeding
  • postcoital bleeding
  • intermittent spotting
24
Q

If there is cervical cancer with microinvasive disease, what is the tx?

A

-CKC or hysterectomy

25
Q

If the cervical cancer is invasive, what do we do?

A

-radical hysterectomy with lymph node dissection

26
Q

IF the cervical cancer has bulky disease, what do we do?

A

-radical hysterectomy with LN direction or radiation therapy and cisplatin based chemotherapy

27
Q

If the cervical cancer is stage 11b or greater, what do we do?

A

-external beam radiation and concurrent cisplatin based chemotherapy

28
Q

What are some ways that we can prevent cervical cancer?

A
  • Abstinence
  • use of barrier protection
  • regular exams and pap smears
  • Vaccination with the HPV vaccine
29
Q

How does the HPV vaccine work?

A
  • 3 injections
  • 1st
  • 2nd 2 months later
  • 3rd 6 months from the first
30
Q

Who is the HPV vaccination recommended for?

A

-all girls and boys ages 9-26

31
Q

What are the 4 strains that Gardasil protects against?

A

-6, 11, 16, 18

32
Q

What are some side effects of HPV vaccine?

A
  • Dizziness
  • nausea
  • headache
  • fever
  • injectiion site rxns