The Oral Environment 2 Flashcards
What are the main salivary proteins?
- Amylase
- Cystatin
- Gustin
- Histatin
- Immunoglobins
- Lactoferrin
- Lactoperoxidase
- Lipase
- Lysozyme
- Mucoproteins
- ‘plasma proteins’
- Proline-rich proteins
- Statherins
What is amylase activated by and what does it require?
- Activated by Cl-
- Requires Ca++
In which salivary gland secretions is amylase present?
In most mucosal gland secretions
What is the role of amylase?
Defence role
Where is lysozyme found in salivary secretions?
Ubiquitous - found everywhere
Is the defence of lysozyme in salivary secretions specific or non-specific?
Non-specific
What is the role of lysozyme in salivary secretions?
Attacks bonds in bacterial cell walls, causing lysis
What is the function of Lactoperoxidase in saliva?
Antibacterial action
What are the functions of cystatins in salivary secretions?
- Inhibit cysteine proteases, especially in bacteria
- Antimicrobial function
What does Gustin contain?
Zinc
Which salivary protein facilitates taste function by activating taste buds?
Gustin
Which salivary protein is a potent PDE 5 activator?
Gustin
PDE 5 is main target for all drugs that treat erectile dysfunction - side effect can be change of taste
Which salivary protein is a histidine-rich protein?
Histatins
What is the function of histatins in saliva?
Antimicrobial
What 2 diseases does histatins in saliva inhibit?
- Candida albicans - fungus that is naturally present in mouth, can eventually take control of mouth if out of control
- Streptococcus mutans - causes caries, has different subtypes and thrives in acidic conditions
Which cells do immunoglobins come from in salivary glands?
Plasma cells