The Neuropathology of dementia - Ismail

Question 1

What type of disorder is Alzheimer’s Disease? (cognitive or motor)

Answer 1

Cognitive

Question 2

What type of disorder is parkinson’s disease?

cognitive or motor

Answer 2

Motor

Question 3

What areas f the brain degenerate in Alzheimer’s disease?

Answer 3

Temporal, parietal and frontal regions

Question 4

What does DLB stand for?

Answer 4

Dementia with Lewy bodies

Question 5

Give an example of cognitive and movement disorder?

Answer 5

Dementia with Lewy bodies

Question 6

What type misfolded protein forms insoluble fibrils when they interact with one another / other cell components?

Answer 6

Beta Amyloid proteins

Question 7

What protein normally stabilizes microtubules in neurons?

Answer 7

Tau proteins

Question 8

What protein normally attaches to other proteins and labels them for destruction?

Answer 8

Ubiquitin

Question 9

What abnormal proteins accumulate intracellularly?

Answer 9

1) Tau
2) alpha-Syncluein
3) Polyglutamine
4) Ubiquitin

Question 10

What abnormal proteins accumulate extracellularly?

Answer 10

Amyloid

Question 11

Disease of which lobes causes impaired judgement, abstract reasoning, strategic planning, emotional restraint, control of appetite and continence?

Answer 11

Frontal lobes

Question 12

Disease of which areas of the brain causes disorders of memory and hallucination?

Answer 12

1) temporal lobe
2) Hippocampus
3) Amygdala
4) Limbic system

Question 13

Disease of which areas of the brain is associated with receptive dysphagia and automatisms?

Answer 13

Temporal neocortex

Question 14

Diseases of which areas of the brain leads to failure of visual sensory systems?

Answer 14

Occipital lobe

Question 15

Diseases of which areas of the brain gives rise to impairment of visuospatial skills / integration of sensory inputs leading to sensory agnosias and apraxias?

Answer 15

Parietal lobe

Question 16

Disease of frontal lobes leads to …

Answer 16

Abnormalities in:

1) judgement
2) abstract reasoning
3) strategic planning
4) emotional restraint
5) control of appetite
6) continence

Question 17

Disease of the temporal lobe, hippocampus., amygdala and limbic system leads to …

Answer 17

Disorders of :

1) memory
2) hallucinations

Question 18

Disease of the temporal neocortex is associated with?

Answer 18

1) receptive dysphagia

2) automatisms

Question 19

Disease of the occipital lobes leads to ?

Answer 19

-failure of visual sensory system

Question 20

Disease of the parietal lobe give rise to?

Answer 20

1) impairment of visuospatial skills
2) impairment of integration of sensory inputs.

Leads to sensory agnosias and apraxia.

• agnosias = inability to process sensory info.
• Apraxia = inability to perform actions

Question 21

What is Braak staging?

Answer 21

A method used to stage alzheimers and parkinsons.

Question 22

Binswanger’s disease

Answer 22

small vessel vascular dementia

Question 23

What is pick’s disease?

Answer 23

frontal lobe dementia