clinical pain

Question 1

Where do non-opiods act?

Answer 1

Non-opiod analgesics such as NSAIDS / COX2 inhibitors actsperipherally.

Question 2

Where do Opioids act?

Answer 2

Opioids act at 2 sites in the spinal cord.

• presynaptically pain signal transmission is reduced.
• postsynaptically membrane is hyperpolarised, decreasing the probability of action potential generation.

Question 3

What type of pain are NSAIDs effective on

Answer 3

mainly nociceptive

Question 4

What type of drug is paracetamol and where does it act?

Answer 4

Paracetamol is a non-opioid analgesic.

Paracetamol acts centrally.

Question 5

What strength of opioids are tramadol and codeine?

Answer 5

weak

Question 6

What strength of opioids are morphine and oxycodone?

Answer 6

stong

Question 7

What opioids should not be used in renal failure?

Answer 7

Morphine or codeine because the sedative metabolites accumulate.

Question 8

where do spinal opioids act?

Answer 8

dorsal horn of cord

Question 9

What is neuropathic pain?

Answer 9

spontaneuous pain and hypersensitivity to pain in association with damage to or a lesion of the nervous system.

Question 10

What does drug therapy for neuropathic pain include?

Answer 10

• antidepressants
• anticonvulsants
• opioids