The Male Reproductive Tract Flashcards

1
Q

Where are the testes originally formed? What stage do they descend into the scrotum?

A

Near the kidneys then they descend to scrotum at approximately 28 weeks of foetal life.

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2
Q

How are the testes guided into the scrotum during development?

A

By the gubernaculum. It is connected to the destination point of the testes and it doesn’t lengthen with development so as the abdomen grows it pulls the testes down into the scrotum.

The walls descend alongside the testes and the fold of peritoneum creates the vaginal process. This then fuses with the peritoneal fold anterior to the testes superiorly forming a space in the testes called the tunica vaginalis.

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3
Q

Why are people with undescended testes infertile?

A

Testes are highly sensitive to temperature

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4
Q

What is the name of the condition where the testes are undescended?

A

Cryptorchidism

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5
Q

How is the tunica vaginalis of the scrotum formed?

A

The walls descend alongside the testes and the fold of peritoneum creates the vaginal process. This then fuses with the peritoneal fold anterior to the testes superiorly forming a space in the testes called the tunica vaginalis. This creates a visceral and parietal layer.

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6
Q

How do the muscles of the scrotum develop?

A

They are extensions of the abdominal wall muscles.

The internal spermatic fascia is derived from the transversalis fascia)

The cremasteric fascia is derived from the itnernal oblique muscle

The external spermatic fascia is derived from external oblique muscle.

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7
Q

Where does the spermatic cord go in the adult?

A

It passes through the inguinal canal.

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8
Q

What structures make up the inguinal canal?

A

Anterior wall and floor: External oblique muscle

External inguinal ring is a slit in fibers of the external oblique aponeurosis above pubic tubercle.

Posterior wall is made up of transversalis fascia.

Internal inguinal ring is midway between anterior superior iliac spine and pubic tubercle above the inguinal ligament.

Roof of canal is formed by fibers of internal oblique and transversus abdominsis

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9
Q

What forms the anterior wall and the floor of the inguinal canal?

A

External oblique muscle

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10
Q

What forms the external inguinal ring of the inguinal canal?

A

Slit in fibers of external oblique aponeurosis above pubic tubercle.

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11
Q

What forms the posterior wall of the inguinal canal?

A

Transversalis fascia

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12
Q

What forms the itnernal inguinal ring of the inguinal canal?

A

Midway between anterior superior iliac spine and pubic tubercle above the inguinal ligament

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13
Q

What forms the roof of the inguinal canal?

A

Fibers of internal oblique and transversus abdominis

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14
Q

What can potentially result from inguinal canal anatomy?

A

Inguinal canal is a weak point in the pelvic wall and so increased abdominal pressure can result in herniation of abdominal viscera into the inguinal canal.

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15
Q

How is an inguinal hernia repaired?

A

Polypropylene mesh is used. This is associated with infertility.

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16
Q

How is temperature regulated in the testes?

A

Cremaster muscle is present in spermatic cord and surrounds testes. It functions to keep testes close to body when cold.

Dartos muscle is just deep to the skin and affects how wrinkled the skin is around the testes.

Abundant sweat glands and a pampiniform plexus which is a venous plexus that runs alongside the testicular artery (countercurrent exchange)

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17
Q

What lymphatics drain the testes?

A

Superficial tissue drains into superficial inguinal nodes.

Glans drains into deep inguinal nodes and external iliac nodes.

The testes themselves drain into the lateral aortic and pre-aortic nodes.

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18
Q

Where is sperm produced?

A

In the seminiferous tubules.(3 to 4 seiminiferous tubules per lobule)

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19
Q

Where does sperm go from the seminiferous tubules?

A

Seminiferous tubules -> Rete testes -> Efferent ductules -> Epididymis -> Vas deferans

20
Q

What do the efferent ductules do?

A

They reabsorb fluid.

21
Q

What does the epididymis do?

A

Sperm maturation (Gain motility, metabolic changes, cell membrane changes - decapacitation) and transport

22
Q

What does the vas deferans do?

A

Storage and Sperm transport.

23
Q

What is the tunica albuginia?

A

The fibrous capsule surrounding the testes

24
Q

What tissue produces androgens in testes?

A

Interstitial tissue (contains leydig cells)

25
Q

What cells are present in seminiferous tubules?

A

Sertoli cells

Germ cells

Immature testis (before puberty): spermatogonia (stem cells that give rise to primary spermatiocytes)

Mature testis: Proliferation of germ cells

26
Q

What are the types of cells seen in the efferent ductules?

A

Pseudostratified columnar epithelium, ciliated and non-ciliated (Fluid reabsorption)

Surrounded by layers of circularly arranged smooth muscle

Re-absorption of fluid from seminiferous tubules.

27
Q

How long does sperm take to pass through the epididymis?

A

2 - 6 days.

28
Q

How does metabolism change of the sperm in the epididymis?

A

Glucose to fructose metabolism

29
Q

What kind of epithelium lines the duct of the epididymis?

A

Pseudostratified columnar epithelium;

Consists of principle cells, basal cells, and halo cells

30
Q

What cells are contained in the duct of the epididymis?

A

Principle (tall) cells with stereocilia (reabsorption cells like microvilli)

Basal cells

Halo cells (main immune cells of epididymis)

31
Q

What regulates changes that occur in the epididymis?

A

Androgens

32
Q

What does the vas deferans look like?

A

35 cm long, thick muscular wall

Palpable and is the site of vasectomy

33
Q

What types of muscles surround the vas deferans?

A

Smooth muscle: 2 longitudinal layers and a circular layer

34
Q

How do the vas deferans move sperm?

A

Peristalsis

35
Q

Where does the ejaculatory duct open into the urethra?

A

Within the prostate gland

36
Q

What do the bulbourethral glands produce?

A

Pre-ejaculatory fluid

37
Q

What do the seminal vesicles produce?

A

Prostaglandins

Clotting proteins

Fructose

38
Q

What does the prostate look like histologically?

A

4 distinct anatomical zones with clinical significance

Round calcifications

39
Q

What does the prostate gland produce?

A

Liquefying enzymes

40
Q

Where do most prostatic cancers arise?

A

In peripheral zone of prostate.

41
Q

Where does benign prostatic hypertrophy usually occur?

A

In the transitional zone

42
Q

What nerves and blood vessels supply the penis?

A

Dorsal vein, artery, and nerve

Deep artery supplies lacunae of corpus cavernosum

43
Q

What is the connective tissue that encapsulates the lacunae of the corpus cavernosum called?

A

Tunica albuginea

44
Q

What causes flaccid penis state?

A

Sympathetic outflow of hypogastric nerve results in contraction of smooth muscle in arteries, arterioles, and sinuses.

Venous drainage is open so blood drains easily.

45
Q

What causes erection?

A

Stimulation of genital region (esp. glans and frenulum) stimulates:

Dorsal nerves -> Pudendal nerve -> S2-S4 (sensory innervation)

This results in Pelvic efferent parasympathetic nerve signals to stimulate nitrous oxide release which relaxes smooth muscles in arterioles and sinuses. This increases bloodflow to sinuses.

Venous drainage is compressed

46
Q

What causes emission and ejaculation?

A

Emission:

Sympathetic fibers from hypogastric plexus stimulate smooth muscle of prostate, vas deferans, and seminal vesicles to contract their contents into the urethra

Ejaculation: Sensory signals of semen in urethra via internal pudendal nerve. SNS then stimulate smooth muscles in the urethra and cause the internal urethral sphincter to contract. Somatic motor neurons cause contraction of bulbospongiosus muscle.