The lumpy horse Flashcards

1
Q

what horses generally get melanomas

A

mostly grey horses
usually develop between 4-8 yrs

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2
Q

List the 4 types of equine melanoma

A

melanocytic nevi
dermal melanoma
dermal melanomatosis
malignant melanoma

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3
Q

what are the characteristic of melanocytic nevi

A

single or multiple discrete nodules

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4
Q

what are the characteristics of dermal melanoma

A

Originate in deeper dermis
Small singular or multiple nodules

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5
Q

what are the characteristics of dermal melanomatosis

A

Confluent large melanomas
Increased risk of metastasis

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6
Q

What are the charcteristics of malignant melanoma

A

Not common, invasive
In older horses
Recurrence very likely

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7
Q

List 4 typical locations of equine melanomas

A

Tail
Perineum
Parotid region
Commissure of lips/eyes

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8
Q

How to diagnose equine melanomas

A

Visual inspection
Palpation
Ultrasound
Fine needle aspiration

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9
Q

Decsribe anaplastic/ amelanotic malignant melanoma

A

Non grey and grey horses
Older horses
Tail and tailhead +++

Have metastasised by the time of diagnosis
Rare

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10
Q

List the key features of equine sarcoids

A

Benign
Non-metastatic
Locally aggressive
In all equids
High recurrence

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11
Q

List the 6 types of equine sarcoids

A

Occult
verrucose
nodular
fibroblastic
mixed
malignant

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12
Q

Describe occult equine sarcoids

A

occur in hairless skin
1 or more small (2-5 cm) cutaneous nodules
Mildest/most stable/superficial form of sarcoid

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13
Q

Describe verrucose sarcoids

A

Rarely aggressive
Rough hyperkeratotic appearance with some flaking or scaling
Warty-looking

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14
Q

Describe nodular sarcoids

A

Very variable sizes, 0.5 to 20 cm
Firm, spherical, subcutaneous nodules
Two types

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15
Q

What are the 2 types of nodular sarcoids

A

A: confined to subcutaneous tissues
B: some involvement of overlying skin

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16
Q

Describe fibroblastic sarcoids

A

Ulcerated, fleshy, aggressive appearance
2 types

17
Q

Describe the 2 types of fibroblastic sarcoids

A

1: Pedunculated with limited/small base palpable under the skin
2: wide base, often diffuse/ill-defined margins

18
Q

Decsribe malignant/ Malevolent sarcoids

A

Most severe, highly invasive- Infiltration of lymphatic vessels
Often following trauma or failed treatment

Cord of palpable tumour

18
Q

Decsribe mixed sarcoids

A

Mixture of two or more types of sarcoid

Vary between verrucous/occult/nodular to fibroblastic

19
Q

what is the most common skin cancer of horses

A

equine sarcoids

20
Q

Describe transmission equine sarcoids

A

Not fully understood
possibly due to contact with sarcoids or contact with cattle/ horses carrying bovine papilloma virus

20
Q

Decsribe the key features of equine squamous cell carcinoma

A

Locally invasive, does metastasise

21
Q

List 5 predilections for squamous cell carcinomas

A

areas lacking pigmentation
poorly haired
mucocutaneous junctions
external genitalia
eye/adnexa

22
Q

List 4 predisposing factors to equine squamous cell carcinomas

A

Equus Caballus papillomavirus 2 (EcPV2) and others
Flies
Smegma
Ultraviolet light exposure

22
Q

Lust the 2 types of surgical excision of equine skin cancers

A

sharp excision
laser excision- currently favoured for sarcoid - and used a lot for melanoma

23
Q

when can banding be used to treat sarcoids

A

only for sarcoids with a thin peduncle
Not to be used if the mass has a root
Takes a few weeks

24
Q

when do we use topical chemotherapeutics for skin masses

A

for low mass burden only
DON’T use very close to eyes

25
Q

Describe electrochemotherapy

A

uses electrical field pulses to induce increased cell membrane permeability to certain antitumour hydrophilic drug like cisplatin

26
Q

List 2 topical chemotherapy creams

A

5-fluorouracil
Mitomycin C

27
Q

List 4 drugs that can be used for intralesional chemotherapy

A

Mitomycin C
Tigilinol tiglate
5 Fluorouracil
Platinum- based e.g. cisplatin or Carboplatin