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Pharmacokinetics > The effects of age on pharmacokinetics > Flashcards

The effects of age on pharmacokinetics Flashcards

1
Q

What is the definition for a neonate?

A

0 - 27 days of life.

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2
Q

How do you work out the corrected age?

A

Chronological age - prematurity

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3
Q

What is the definition for an infant?

A

28 days - 1 year.

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4
Q

What is the definition for a child?

A

1 - 18 years.

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5
Q

What is the definition for chronological age?

A

Age from birth to the current date.

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6
Q

What is the definition for gestational age at birth?

A

Length of pregnancy from first day of mother’s last menstrual cycle to birth date.

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7
Q

What is the definition for post menstrual age?

A

Gestational age + Chronological age.

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8
Q

How to work out the corrected age for pre - term neonates?

A

Chronological age - degree of prematurity.

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9
Q

What is the % of fat in drug distribution for neonates?

A

10%

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10
Q

What is the % of fat in drug distribution for adults?

A

25 - 30%

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11
Q

What is the effect on drug distribution for water soluble drugs?

A

HIGHER volume of distribution for water - soluble drugs in neonates.

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12
Q

What is the effect on drug distribution for fat soluble drugs?

A

HIGHER volume of distribution for fat - soluble drugs in children and adults.

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13
Q

What is the plasma protein concentration like in neonates and children compared to adults?

A

It’s LOWER in neonates and children compare to adults.

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14
Q

At what age are full adult levels reached regarding phase 1 reactions?

A

At the age of 1 to 2 years.

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15
Q

When is the adult rate reached for renal function?

A

Adults rate is reached towards the end of the first year of life.

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16
Q

What happens to total body water and central body fat with age?

A

Total body water DEREASES.

Central body fat INCREASES.

17
Q

What happens to volume of distribution for hydrophilic and lipophilic drugs with age?

A

Hydrophilic Drugs = DECREASES.

Lipophilic Drugs = INCREASES.

18
Q

What happens to renal function and excretion of drugs with age?

A

Both DECREASE.

19
Q

By how much is there are reduction in blood flow and liver volume when you reach the age of 90?

A

30 - 60% reduction.

Pharmacokinetics (18 decks)

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