Factors affecting elimination Flashcards
1
Q
What are the fluid sites of drug excretion?
A
Urine / Bile / Sweat / Tears / Breast Milk
2
Q
What are the solid sites of drug excretion?
A
Faeces / Hair
3
Q
What are the gas sites of drug excretion?
A
Exhaled Breath
4
Q
What are the factors which determine filtration of drugs?
A
- Molecular Size
- Charge
- Protein Binding
5
Q
How does molecular size affect the filtration of drugs?
A
Molecules of molecular weight LESS than 20 kDA may pass freely.
6
Q
How does charge affect the filtration of drugs?
A
Glomerular capillary wall is negatively charged.
Reduces the filtration of anions
7
Q
How does protein binding affect the filtration of drugs?
A
Only ‘free drug’ may be filtered.
