Concentration - Effect Curves Flashcards
What is the theoretical relationship between concentration and effect?
Linear Relationship.
What does the threshold level mean?
This is the level at which effects are seen.
What line is used to determine the relationship between concentration and effect?
A hyperbolic line is used = as it is a non - linear relationship.
What is the purpose of log - transformation?
Used to view the data regarding the link between concentration and effect.
Which coefficient theory is used to support the Emax model?
The Hill Coefficient theory is used.
Explain more about the ‘Hill Coefficient Theory.’
Haemoglobin has 4 binding sites for oxygen = as each is filled, the affinity for oxygen of the others INCREASES.
What happens to the affinity of the drug as MORE receptor sets are occupied?
Affinity for the drug INCREASES.
What happens to the number of sites occupied as the concentration increases?
The number of sites INCREASES.
