The Anti-inflammatory Effects of Exercise

Question 1

What are some anti inflammatory effects of exercise IL6

Answer 1

Inhibit pro-inflammatory cytokines like TNFA & IL-1b

stimulate IL-10 which is anti-inflammatory

Stimulate cortisol secretion, anti-inflammatory

simulate CRP - which induces anti-inflammatory cytokines

Question 2

What are some typical elevated markers in chronic inflammation ?

Answer 2

IL-6
CRP
TNFA

Question 3

How can inflammation be a cause for atherosclerosis?

Answer 3

Oxidized LDL penetrates intima which activates macrophages.

The macrophages kill the LDL, but doing releases PRO IL1b.

The macrophages develop into foam cells, a plaque,

Fibrous cap covers this and if it splits causes thrombosis of infarction.

Question 4

How can acute exercise effect inflammation ?

Answer 4

It lowers all TLR expression, meaning the down steam responses that can cause upregulation of Inflammatory responses.

Question 5

What did Lancaster 2006 shown about Inflammatory response and LPS stimulation

Answer 5

As LPS binds to TLR4, stimulation of this will upregulate immune responses by increasing expression of CD86 and MHCII

Question 6

How does chronic exercise training effect TLR4 expression ?

Answer 6

It reduced it, meaning reduced inflammation.

Question 7

What has been shown among training groups for treg content ?

Answer 7

those who are trainer to higher intensities and for greater volumes have more treg producing cells, hence IL-10.

Question 8

Are Higher Il-10 circualting contenst good.

Answer 8

Yes for chronic metabolic disease prevention, however, it does increase incidence of URTI.