Temperature & The Inflammatory Response Flashcards
1
Q
Why does body temp rise during a fever ?
A
- Killing of heat sensitive pathogens
- Improved immune function
2
Q
What are heat shock proteins?
A
Within the cell they have chaperone functions
Outside of the cell there have similar effects to cytokines.
3
Q
How are heat shock proteins released from the cell?
A
Either through cell disintegration during exercise or situations such as stress,
of the cell can willingly realse them.
4
Q
What can heat shock proteins do when the leave the cell?
A
Signal cytokines or chemokines
5
Q
What is the associated effect of iHSP vs eHSP ?
A
iHSP - inhibits NFKB, thus anit-inflammatory effect
eHSP - Stimulate TLR4, thus pro inflammatory pathways of NFKb and JNK, which leads to cytokine production and Blunted insulin reaction.
