The 3 Rs Flashcards
1
Q
What are the three rs
A
-reduvction
- refienment
- replacement
2
Q
What is reduction?
A
- getting the number of animals right
- avioding duplication
- avioding poor experimental design
3
Q
What is refienment?
A
- reducing the severity of the procedure
- difficulty of assessing animal stress
4
Q
What is replacement?
A
- mathimatical/ computor models
- lower organisums
- early developmental stages
- in vitro methods
- human studies
- validation is a big issue
5
Q
How is in vitro form of replacement benificial?
A
- greater control of cell environment
- greater knowledge of what is happening
- more repeatable than some animal models
6
Q
What are the short comings of using plant for replacrement?
A
- ligands to which bacteria bind are different
- bacterial toxins dont circulate plants
cross kingdom pathogenicity in few plant taxa - virulence factors different across kingdoms
7
Q
The use of computor systems for replacement?
A
- many applications
- predicting amyloid fibril clusters
- only as good as the data model
