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ENS632 (Test #2 V2) > TG Synthesis > Flashcards

TG Synthesis Flashcards

1
Q

What is the the Acronym for memorizing the TG synthesis pathway?

A

MLP-DDT

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2
Q

What is the 1st step of TG Synthesis?

A

FA Acel CoA + G3P create M3P

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3
Q

What is the enzyme that converts FA Acel CoA + G3P into M3P?

A

GPAT *(rate limiting)

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4
Q

What is the 2nd step of TG Synthesis?

A

M3P is converted into Lysophosphatidate

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5
Q

What is the enzyme that converts M3P into Lysophosphatidate

A

LPAT

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6
Q

What is the 3rd step of TG Synthesis?

A

Lysophosphatidate is converted into Phoshatidate

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7
Q

What is the enzyme that converts Lysophosphatidate into Phoshatidate?

A

AGPAT

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8
Q

What is the 4th step of TG Synthesis?

A

Phoshatidate is converted into Diacylglycerol

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9
Q

What is the enzyme that converts Phoshatidate into Diacylglycerol?

A

PAP

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10
Q

What is the 5th step of TG Synthesis?

A

Diacylglycerol is converted into a Diglyceride (DG)

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11
Q

What is the 6th step of TG Synthesis?

A

Diglyceride is converted into a Triglyceride

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12
Q

What is the enzyme that converts a DG into a TG?

A

DGAT

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13
Q

Where are most of the enzymes used for TG synthesis originating from?

A

They are all embedded in the mitochondrial membrane

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14
Q

What is an acronym for remembering the enzymes of TG synthesis?

A

GLAPD

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15
Q

What hormone is needed to activate the enzymes of TG synthesis?

A

Insulin

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16
Q

What is inputed into each step of TG synthesis?

A

FA’s (except step 4: H20 inputed)

17
Q

What is the rate limiting enzyme of TG Synthesis?

A

GPAT

18
Q

What are some substate sources of allosteric activation of TG Synthesis?

A

High G3P
High FA Acel CoA
High DGAT

19
Q

Insulin and ____ act to de-phosphoralate enzymes to make them active and subsequently regulate TG Synthesis?

A

CPT-1

20
Q

PKA phosphorylates what to do what to TG Synthesis?

A

DGAT (renders enzyme inactive) > preventing TG Synthesis

21
Q

PKA phosphorylates what to activate Lipolysis?

A

HSL

22
Q

To much of what = no fat breakdown?

A

ATP

23
Q

Insulin has what effect on Lipolysis?

A

Turns it off so it can make TG’s for storage.

ENS632 (Test #2 V2) (7 decks)

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