TG Synthesis Flashcards
What is the the Acronym for memorizing the TG synthesis pathway?
MLP-DDT
What is the 1st step of TG Synthesis?
FA Acel CoA + G3P create M3P
What is the enzyme that converts FA Acel CoA + G3P into M3P?
GPAT *(rate limiting)
What is the 2nd step of TG Synthesis?
M3P is converted into Lysophosphatidate
What is the enzyme that converts M3P into Lysophosphatidate
LPAT
What is the 3rd step of TG Synthesis?
Lysophosphatidate is converted into Phoshatidate
What is the enzyme that converts Lysophosphatidate into Phoshatidate?
AGPAT
What is the 4th step of TG Synthesis?
Phoshatidate is converted into Diacylglycerol
What is the enzyme that converts Phoshatidate into Diacylglycerol?
PAP
What is the 5th step of TG Synthesis?
Diacylglycerol is converted into a Diglyceride (DG)
What is the 6th step of TG Synthesis?
Diglyceride is converted into a Triglyceride
What is the enzyme that converts a DG into a TG?
DGAT
Where are most of the enzymes used for TG synthesis originating from?
They are all embedded in the mitochondrial membrane
What is an acronym for remembering the enzymes of TG synthesis?
GLAPD
What hormone is needed to activate the enzymes of TG synthesis?
Insulin
What is inputed into each step of TG synthesis?
FA’s (except step 4: H20 inputed)
What is the rate limiting enzyme of TG Synthesis?
GPAT
What are some substate sources of allosteric activation of TG Synthesis?
High G3P
High FA Acel CoA
High DGAT
Insulin and ____ act to de-phosphoralate enzymes to make them active and subsequently regulate TG Synthesis?
CPT-1
PKA phosphorylates what to do what to TG Synthesis?
DGAT (renders enzyme inactive) > preventing TG Synthesis
PKA phosphorylates what to activate Lipolysis?
HSL
To much of what = no fat breakdown?
ATP
Insulin has what effect on Lipolysis?
Turns it off so it can make TG’s for storage.
