Lipogenesis / Chain-Elongation Flashcards
What is Lipogenesis?
Creation of Long Chain Fatty Acids for Fat Storage
When does Lipogenesis occur?
Too much or excess CHO
What are the 4 steps of Lipogenesis?
1.) Condensation
2.) Reduction
3.) Dehydration
4.) Reduction
Excess CHO in the blood stream will end up where and create what?
CHO > Blood Stream > Liver
Liver uses insulin to make glucose into Glycogen
Where is Insulin secreted from for use in the liver?
Pancreas (Beta Cells)
Once glycogenisis has packed the liver full of glycogen storage, where will remaining glycogen go?
It will convert into Acetyl CoA for use in Lipogenesis
What molecule is the foundation for FA Elongation?
Fatty Acid Synthase (FAS) + ACP
What is the base step #1 of Elongation?
FAS + ACP + Acetyl CoA
What is base step #2 of Elongation?
MCA is added to the base elongation step of FAS + ACP + Acetyl CoA
What step 1 of Lipogenesis (condensation)?
MCA + Acetyl CoA convert into KetoAcel ACP
What is the enzyme that converts MCA + Acetyl CoA into KetoAcel ACP?
KetoAcel ACP Synthase
What is Step 2 of Lipogenesis (Reduction)?
KetoAcel ACP is converted into HydroxyAcel ACP
What is the enzyme that converts KetoAcel ACP into HydroxyAcel ACP?
KetoAcel ACP Reductase
What are the byproducts of step 2 of Lipogenesis?
NADH > NAD
What is step 3 of Lipogenesis (Dehydration)?
HydroxyAcel ACP is converted into Trans-Enoyl ACP