TG Breakdown Flashcards
What activates TG Breakdown?
EPI/NE
Cortisol
Glucagon
What inhibits TG Breakdown
Glucose
Insulin
What protein activates TG breakdown and acts as a counter to Insulin?
Perilipin-1A
Where are TG stored?
Adipose Cells
How many H20’s are needed for the full breakdown of TG’s?
x3
What enzyme breaks the tail of the 1st ester bond of a TG?
ATGL (Adipose TG Lipase)
When the first tail of a TG molecule undergoes hydrolysis, what does it become?
Diglyceride
What enzyme breaks the tail of the 2nd ester bond of a TG?
HSL (Hormone Sensitive Lipase)
When the second tail of a DG molecule undergoes hydrolysis, what does it become?
Monoglyceride
Once broken down, FFA, Glycerol, and MG go where?
They cross into the Enterocytes of the intestinal epithelium
Once inside the enterocytes, what do FFA, Glycerol, and MG do?
Reform into TG’s and add a Cholesterol to become a Chylomicron
Chylomicron = what?
TG + Cholesterol
When a Chylomicron is formed, where does it head to after formation?
Leaves the enterocytes, into the blood stream.
How are Chylomicrons transported to Tissues (i.e. pass through capillary walls of tissue)
LPL (lipoprotein lipase)
