Tetracyclines

Question 1

Tetracycline MOA

Answer 1

Binds to 30s ribosomal subunit inhibiting bacterial protein synthesis causing a defective cell membrane

Question 2

Tetracycline coverage

Answer 2

G+
G- bacteria/flora (Haemophilus, Moraxella, atypical)
Unique pathogens (spirochetes, trepenoma pallidum, rickettsiae)

Question 3

Respiratory tract, STDs, tick illnesses, CA-MRSA, VRE

Answer 3

Doxycycline

Question 4

Skin Infections, Acne

Answer 4

Minocycline

Question 5

Doxycycline (Vibramycin)

Answer 5

PO/IV: 100 - 200mg QD

w/ food

Question 6

Minocycline (Minocin, Solodyn)

Answer 6

PO/IV: 200mg x1 then 50 - 100mg Q12h

Question 7

Tetracycline

Answer 7

PO: 250 - 500mg Q6h

Empty stomach

Question 8

Warning

Answer 8

Kids <8/pregnancy/breastfeeding: discolor teeth, bone suppression
Photosensitivity
Skin rxns
Minocycline: DiLupusE

Question 9

Side Effects

Answer 9

N/V/D

rash

Question 10

Monitoring

Answer 10

LFTs
Renal function
CBC

Question 11

Drug Interactions

Answer 11

Antacids
Polyvalent cations
Food decrease GI upset
Lanthanum
Tetracycline: CYP inhibitors/inducers/substrates
Warfarin - Incr. effect of warfarin
Neuromuscular blockers - Incr. effect of blockers