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Antibiotics > Macrolides > Flashcards

Macrolides Flashcards

1
Q

Macrolide MOA

A

Bind to 50s ribosomal subunit inhibiting bacterial protein synthesis causing a defective cell membrane

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2
Q

Macrolide coverage

A

Atypicals & Haemophilus

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3
Q

STDs

A

Chlamydia

Gonorrhea

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4
Q

Azithromycin (Zithromax, Z-Pak)

A

Z-Pak: 500 mg day 1, 250 mg days 2-5
Tri-Pak- 500mg x 3d
IV: 250 - 500mg QD

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5
Q

Clarithromycin (Biaxin)

A

PO: 250 - 500mg Q12h
XL: 1g QD

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6
Q

Erythromycin (EES)

A

PO: 400mg = 250 erythromycin base

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7
Q

Contraindications

A

Hepatic dysfunction or jaundice
Use w/ lovastatin/simvastatin, ergotamine/dihydroergotamine
Clarithromycin: colchicine in renal/hepatic impairment, QT prolongation, ventricular arrhythmia

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8
Q

Side effects

A

GI upset
Ototoxicity
skin rxns
taste change

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9
Q

Drug Interactions

A 
CYP 3A4 inhibitors/inducers/substrates (Erythro/clarithro)
Simvastatin/Lovastatin
Warfarin
Apixaban
Dabigatran
Rivaroxaban
Azithromycin: strong CYP 3A4 inhibitors/inducers
Low K+, Mg 2+, QT Prolonging drugs
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Antibiotics (7 decks)

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