Quinolones

Question 1

Quinolone MOA

Answer 1

Inhibit bacterial DNA topoisomerase 4 and DNA gyrase (topoisomerase 2) to prevent DNA supercoiling and promote breakage

Question 2

Quinolone coverage

Answer 2

G-, G+, atypical

Question 3

Respiratory Quinolones - Strep pneumo & atypical

Answer 3

Gemifloxacin
Levofloxacin
Moxifloxacin

Question 4

Pseudomonas Coverage - combo w/ B-lactam

Answer 4

Ciprofloxacin

Levofloxacin

Question 5

G+ & anaerobic coverage

Answer 5

Moxifloxacin - NO UTI

Question 6

MRSA

Answer 6

Delafloxacin

Question 7

Ciprofloxacin

Answer 7

PO: 250 - 750mg Q12h
IV: 200 - 400mg Q8-12h
CrCl <50: Q12h
CrCl <30: Q18-24h

Question 8

Delafloxacin

Answer 8

PO: 450mg Q12h
IV: 200 - 400mg Q8-12h
CrCl <30 IV only
CrCl <15 mL/min no IV/PO

Question 9

Gemifloxacin

Answer 9

PO: 320mg QD

Question 10

Levofloxacin (Levaquin)

Answer 10

PO/IV: 250 - 750mg QD

CrCl <50 mL/min Q48h

Question 11

Moxifloxacin (Avelox)

Answer 11

IV/PO: 400mg QD

Question 12

Ofloxacin

Answer 12

PO: 200 - 400mg Q12h

Question 13

BBW

Answer 13

Tendon inflammation/rupture
Peripheral neuropathy
CNS: Seizures, Confusion, Hallucinations, Insomnia

Question 14

Contraindications

Answer 14

Ciprofloxacin w/ Tizanidine

Question 15

Side Effects

Answer 15

N/D skin rxns

Question 16

Warning

Answer 16

QT prolongation (moxifloxacin)
Glycemic dysregulation
psychiatric disturbances
NO quinolones in children/pregnancy/breastfeeding

Question 17

Drug Interactions

Answer 17

Antacids
Polyvalent cations
Lanthanum Carbonate (fosrenol)
Sevelamer
Warfarin - Incr warfarin effect
Hypoglycemics - Incr hypoglycemic effect 
QT prolongation
Probenecid - Incr. quinolone lvl
NSAIDs - Incr. quinolone lvl
Caffeine/Theophylline - 1A2 inhibition