Penicillins

Question 1

Penicillin VK

Answer 1

PO: 125 - 500mg Q6-12h

empty stomach

Question 2

Pen G Aqueous

Answer 2

IV: 2 - 4 mill units Q4-6h

Question 3

Pen G Benzathine

Answer 3

IM: 1.2 - 2.4 mill units

Question 4

Amoxicillin (Moxatag)

Answer 4

PO: 0.5 - 1g Q8-12h

Question 5

Amoxicillin/Clavulanate (Augmentin)

Answer 5

PO: 500 mg Q8-12h

Question 6

Ampicillin

Answer 6

IV/IM: 1 - 2g Q4-6h

Question 7

Ampicillin/Sulbactam (Unasyn)

Answer 7

IV: 1.5 - 3g Q6h

Question 8

Zosyn

Answer 8

IV: 3.375g Q6h

4.5g Q6-8h

Question 9

Dicloxacillin

Answer 9

PO: 125 - 500mg Q6h

Question 10

Nafcillin

Answer 10

IV/IM: 1 - 2g Q4-6h

Question 11

Oxacillin

Answer 11

IV: 0.25 - 2g Q4-6h

Question 12

Natural penicillin coverage

Answer 12

G+ cocci (Strep & Entero)

Question 13

Aminopenicillin coverage

Answer 13

Natural penicillin + G+ anaerobe (mouth flora) + HNPEK)

Question 14

Extended Spectrum Penicillin coverage

Answer 14

SPACEcK + Pseudomonas

Question 15

Antistaph penicillins coverage

Answer 15

Strep & MSSA no Entero

Question 16

Penicillin BBW

Answer 16

Pen G Benzathine - no IV

Question 17

Penicillin Contraindications

Answer 17

ESP Aminopenicillins - liver dysfunction & jaundice

CrCl <30 mL/min

Question 18

Penicillin Side Effects

Answer 18

Seizures (accumulation)
GI upset
Rash
Increased LFTS

Question 19

Penicillin Monitoring

Answer 19

Renal function
Anaphylaxis
CBC
LFTs

Question 20

Penicillin Drug Interactions

Answer 20

Probenecid - decreased renal excretion
Warfarin - increased coagulation (not nafcillin/dicloxacillin)
MTX - increased MTX lvl
Mycophenolate - decreased Mycophenolate lvl