Cephalosporins

Question 1

Cephalosporin Coverage

Answer 1

Varies w/ generation

No Entero nor atypical

Question 2

Cephalosporin 1st gen coverage

Answer 2

G+ cocci (strep & staph)
MSSA preferred
G- rods (PEK)

Question 3

Cephalosporin 2nd gen coverage

Answer 3

Cefuroxime - HNPEK

Cefotetan/Cefoxitin - HNPEK + B. Fragilis (G- anaerobe)

Question 4

Cephalosporin 3rd gen coverage

Answer 4

Ceftriaxone/Cefotaxime/oral - 1st gen + HNPEK
Ceftazidime - pseudomonas
Ceftazidime/avibactam, ceftolozane/tazobactam - MDR pseudomonas & MDR G- rods (SPACEcK)

Question 5

Cephalosporin 4th gen coverage

Answer 5

Cefepime - HNPECK, SPACEcK, Pseudomonas, ceftriaxone

Question 6

Cephalosporin 5th gen coverage

Answer 6

Ceftaroline - ceftriaxone, MRSA

Question 7

1 Cefazolin (ancef)

Answer 7

IV/IM: 1 - 1.5g Q8h

Question 8

1 Cephalexin (keflex)

Answer 8

PO: 250 - 500mg Q6-12h

Question 9

1 Cefadroxil

Answer 9

PO: 1 - 2g Q12-24h

Question 10

2 Cefuroxime (Ceftin)

Answer 10

PO/IV/IM: 0.25-1.5g Q8-12h

Question 11

2 Cefotetan (Cefotan)

Answer 11

IV/IM: 1 - 2g Q12h

Question 12

2 Cefaclor

Answer 12

Po: 250 - 500mg Q8h

Question 13

2 Cefoxitin

Answer 13

IV/IM 1 -2g Q6-8h

Question 14

2 Cefprozil

Answer 14

PO: 250 - 500mg Q12-24h

Question 15

3-1 Cefdinir (Omnicef)

Answer 15

PO: 300mg Q12h or 600mg Q24h

Question 16

3-1 Ceftriaxone (Rocephin)

Answer 16

IV/IM: 1 - 2g Q12-24h

Question 17

3-1 Cefotaxime

Answer 17

IV/IM: 1 - 2g Q4-12h

Question 18

3-1 Cefpodoxime

Answer 18

100 - 400mg Q12h

Question 19

3-2 Ceftazidime (Fortaz, Tazicef)

Answer 19

IV/IM: 1 - 2g Q8-12h

Question 20

3-2 Avycaz

Answer 20

2.5g Q8h

Question 21

3-2 Zerbaxa

Answer 21

1.5g Q8h

Question 22

4 Cefepime (Maxipime)

Answer 22

IV/IM: 1 - 2g Q8-12h

Question 23

5 Ceftaroline (Teflaro)

Answer 23

IV: 600mg Q12h

Question 24

Cephalosporin Drug Interactions

Answer 24

Drugs that decrease stomach acid - PPIs, H2RAs

Question 25

Cephalosporin Contraindications

Answer 25

Hyperbilirubinemic neonates

Ca2+ containing IVs in <28d

Question 26

Cephalosporin Side Effects

Answer 26

Seizures (Renal failure)
GI upset
Rash
Incr. LFTs

Question 27

Cephalosporin Monitoring

Answer 27

Renal Function
anaphylaxis
CBC
LFTs

Question 28

Cephalosporin Outpatient Oral

Answer 28

1. Cephalexin (Keflex) - (250 - 500mg Q6-12h)
2. Cefuroxime (0.25-1.5g Q8-12h)
3. Cefdinir (300mg Q12h or 600mg Q24h)

Question 29

Cephalosporin Inpatient Parenteral

Answer 29

1. Cefazolin
2. Cefotetan/Cefoxitin
3. Ceftriaxone/Cefotaxime/Ceftazidime/Avycaz/Zerbaxa
4. Cefepime
5. Ceftaroline