Tetracycline Flashcards
DOC for chlamydia
tetracycline: doxycycline
macrolide: azithromycin
free forms of tetracycline
crystalline amphoteric substances (low lipid solubility)
tetracycline hydrochloride
higher lipid solubility
t/f: in the presence of di and trivalent metal ions, they tend to impair the absorption and antibacterial activity of tetracycline
true.
t/f: do not give tetracyclines at the same time with preparations containing ions like milk dairy products and antacids
true
t/f: tetracyclines have good absorption in local areas like eyes and in mucous membranes and skin
true
mechanism in the development of resistance
decreased influx
ribosomal protection
enzymatic inactivation
short acting preparations (6-8hrs)
chlortetracycline
tetracycline
TetraChlor
intermediate acting preparations (12hrs)
demeclocycline
methacycline
DeMet
long acting preparations (16-18hrs)
doxycycline
minocycline
DoMino
tetracyclines are impaired by food except
doxycycline
minocycline
t/f: tetracycline is impaired by presence of alkaline ph
true
t/f: tetracyclines have high concentrations on saliva and tears
true
t/f: tetracycline ms can be passed thru placenta and breastmilk
true
excretion of tetracycline
almost equal: renal and biliary. most are excreted thru renal. exception: doxycycline and tigecycline (biliary)
