Cephalosporins

Question 1

moa of cephalosporins

Answer 1

inh of cell wall synthesis. same target in transpeptidation with cephalosporin binding protein

Question 2

most common adverse reaction for cephalosporins

Answer 2

hypersensitivity

Question 3

t/f: cephalosporins are more stable than penicillins

Answer 3

true. cephalosporins are not easily destroyed by beta lactamase esp members of 4th and 5th gen

Question 4

t/f: cephalosporins have broader spectrum of activity than penicillins

Answer 4

true. because they are more resistant to beta-lactamase

Question 5

t/f: whatever substituent or radical is attached to R1 or R2 will make Cephalosporin unique.

Answer 5

true

Question 6

1st gen cephalosporins

Answer 6

Cephalexin, cephadroxil

cephalotin, cephaloridine

cephradine

Question 7

2nd gen cephalosporins

extended activity against G(-) organisms

Answer 7

cefaclor, cefprozil

cefamycin, cefoxitin, cefotetan, cefmetazole, cefuroxime

Question 8

3rd gen cephalosporins

-extended spectrum against G (-) organisms, especially rarely encountered organisms

Answer 8

cefixime, cefdinir, ceftibuten

cefoxatime, ceftazidime, ceftriaxone

Question 9

drugs used in pseudomonas infection

Answer 9

ceftazidime, cefoperazone

Question 10

4th generation cephalosporins: more resistant to beta lactamase producing enterobacter

Answer 10

cefepime, cefpirome

Question 11

5th generation celhalosporins: activity effective against MRSA

Answer 11

ceftobiprole

Question 12

cephalosporins are excreted thru

Answer 12

renal

some are excreted biliary: cefoperazone, ceftriaxone

Question 13

drugs associated with renal complications

Answer 13

cephaloridine

Question 14

drugs associated with hypothrombinemia and bleeding disorders

Answer 14

those that contain methylthiotetrazole group:

cefamandole
cefmetazole
cefotetan
cefoperazone

AmanMetOtetOpera