Macrolide Flashcards
chemistry
macrocyclic lactone ring to which desosamine and cladinose are attached
moa
binds 50s ribosomal subunit near peptidyl transferase center
development of resistance
reduced permeability or efflux
enzyme inactivation
ribosomal protection
effect of erythromycin estolate in adults
cholestatic hepatitis
effect of erythromycin estolate in pediatrics
preferred because it is well tolerated and best absorbed
t/f: erythromycin can be destroyed by HCl in the stomach
true
there is interference of food except:
stearate
esters
excretion is thru
bile
5% renal
erythromycin is the DOC for
corynebacterial infections
campylobacter jejuni infection
h. pylori infection
DOC for legionella
azithromycin
DOC for chlamydia trachomatis
azithromycin
DOC for atypical pneumonia
macrolides
most common adverse effect
GI intolerance
clarithromycin, there is an addition of what, improving acid stability and oral absorption
methyl group on C6
used as one of the antibiotics in the treatment of superinfection associated with AIDS
clarithromycin
t/f: clarithromycin > erythromycin on spectrum of activity
true
active metabolite if clarithromycin
14- hydroxyclarithromycin
t/f: clarithromycin has lower incidence of GI intolerance
true
there is a presence of what in azithromycin
methylated nitrogen group
t/f: azithromycin has no significant drug to drug interaction on CYP450
true
azithromycin activity on
mycobacterium avium complex
toxoplasma gondii
t/f: azithromycin has less activity against strep and staph compare to erythromycin
true
t/f: azithromycin has slightly greater activity against h. influenzae
true
first ketolide prototype,
there is an alteration in carbon 3
telithromycin
