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Antibiotics > Macrolide > Flashcards

Macrolide Flashcards

1
Q

chemistry

A

macrocyclic lactone ring to which desosamine and cladinose are attached

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2
Q

moa

A

binds 50s ribosomal subunit near peptidyl transferase center

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3
Q

development of resistance

A

reduced permeability or efflux
enzyme inactivation
ribosomal protection

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4
Q

effect of erythromycin estolate in adults

A

cholestatic hepatitis

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5
Q

effect of erythromycin estolate in pediatrics

A

preferred because it is well tolerated and best absorbed

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6
Q

t/f: erythromycin can be destroyed by HCl in the stomach

A

true

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7
Q

there is interference of food except:

A

stearate

esters

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8
Q

excretion is thru

A

bile

5% renal

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9
Q

erythromycin is the DOC for

A

corynebacterial infections
campylobacter jejuni infection
h. pylori infection

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10
Q

DOC for legionella

A

azithromycin

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11
Q

DOC for chlamydia trachomatis

A

azithromycin

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12
Q

DOC for atypical pneumonia

A

macrolides

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13
Q

most common adverse effect

A

GI intolerance

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14
Q

clarithromycin, there is an addition of what, improving acid stability and oral absorption

A

methyl group on C6

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15
Q

used as one of the antibiotics in the treatment of superinfection associated with AIDS

A

clarithromycin

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16
Q

t/f: clarithromycin > erythromycin on spectrum of activity

A

true

17
Q

active metabolite if clarithromycin

A

14- hydroxyclarithromycin

18
Q

t/f: clarithromycin has lower incidence of GI intolerance

A

true

19
Q

there is a presence of what in azithromycin

A

methylated nitrogen group

20
Q

t/f: azithromycin has no significant drug to drug interaction on CYP450

A

true

21
Q

azithromycin activity on

A

mycobacterium avium complex

toxoplasma gondii

22
Q

t/f: azithromycin has less activity against strep and staph compare to erythromycin

A

true

23
Q

t/f: azithromycin has slightly greater activity against h. influenzae

A

true

24
Q

first ketolide prototype,

there is an alteration in carbon 3

A

telithromycin

Antibiotics (11 decks)

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