Carbapenems Flashcards
1
Q
prototype drug
A
imipenem
2
Q
imipinem has good activity against
A
gram negative rods (p. aeruginosa)
gram positive organisms
anaerobes
3
Q
it is inactivated by what enzyme in renal tubules
A
dehydropeptidase.
once it reaches the renal tubules, it becomes easily inactivated by the group enzyme dehydropeptidase present there
4
Q
drug that is combined with imipinem to prevent its degradation
A
cilastatin. a dehydropeptidase inhibitor
5
Q
other carbapenems
A
have slightly greater activity against gram negative aerobes
slightly lesser activity vs gram positive
have no significant dehydropeptidase inactivation
6
Q
high levels of imipinem is contraindicated in patients with
A
renal impairment
with epilepsy
