TEST II

Question 1

Mention 3 Terms associated with contact factors

Answer 1

1. Plasma Kallikrein
2. Factor XII
3. Tissue Factor

Question 2

A name associated with endpoint of secondary hemostasis

Answer 2

cross-linked fibrin

Question 3

what name is associated with active serine proteases that have no cofactor

Answer 3

1. Trypsin
2. Factor XI
3. Thrombin

Question 4

Name Intestinal organisms that produce vitamin K

Answer 4

1. Bacteroides fragilis
2. Escherichia coli

Question 4

what is the regulation factor for factor VII

Answer 4

Tissue factor

Question 5

A term associated with activated prothrombin

Answer 5

Thrombin

Question 6

what is the important difference between activation of primary hemostasis and secondary hemostasis

Answer 6

Primary is activated when there is a small injury while secondary is activated during major injurieswhen tissue factor is exposed

Question 7

Important difference between shear rate laminal flow in arterioles and shear rate in veins

Answer 7

Shear rates in arterioles tend to be higher due to their smaller diameter and faster blood flow while Shear rates in veins are generally lower compared to arterioles

Question 8

one important difference between des-y carboxyl procoagulants and y carboxyl

Answer 8

des-y carboxyl procoagulants: These lack the gamma carboxylation. Without this modification, they cannot effectively bind calcium and therefore have impaired clotting activity while y-carboxyl procoagulants: These possess a gamma (y) carboxyl group attached to specific glutamic acid residues in their protein structure. This carboxylation, dependent on vitamin K, is crucial for their function as clotting factors.

Question 9

one important different between plasninogen and plasmin

Answer 9

Plasminogen is the inactive precursor form of plasmin while Plasmin is an enzyme present in blood that plays a crucial role in fibrinolysis