Lymphomas

Question 1

What causes lymphomas

Answer 1

Epstein-Barr Virus (EBV)
Autoimmunity
Immunocompromised patients

Question 2

What is a hodgkin lymphoma

Answer 2

Is a solid tumor characterized by painless, progressive hypertrophy of lymphoid tissue

Question 3

What are the characteristics of hodgkin lymphoma

Answer 3

1. Contains reed-sternberg cells
2. Reactive white blood cells
3. Splenomegaly. ( increased spleen)

Question 4

What are characteristics of reed sternberg cells

Answer 4

1. They are giant
2. Binucleated
3. Abundant cytoplasm and prominent nucleoli

Question 5

What does the presence of reed sternberg cells signify clinically

Answer 5

Is a definitive histologic characteristic of hodgkin disease

Question 6

Mention the categories/ classes of hodgkin lymphoma

Answer 6

1. Nodular lymphoma ( predominant hodgkin)
2. Classical hodgkin lymphoma

Question 7

What is a Nodular lymphocyte predominant Hodgkin lymphoma

Answer 7

Is a B cell neoplasm composed of relatively rare neoplastic cells ( popcorn cells) scattered within nodules of reactive lymphocyte

Question 8

What is Nodular-lymphocyte predominant Hodgkin lymphoma?

Answer 8

It is a B-cell neoplasm composed of relatively rare neoplastic cells (lymphocytic/histiocytic or “popcorn” cells) scattered within nodules of lymphoid tissue.

Question 9

How is the morphological architecture of the lymph node tissue in nodula lymphocyte hodkin lyphoma

Answer 9

1. It is replaced by a nodular proliferation of small lymphocytes
2. scattered lymphocytic/histiocytic or popcorn cells.

Question 10

What is the composition of the surrounding nodular background?

Answer 10

It’s composed of CD20+ small cells and scattered T lymphocytes.

Question 11

What type of cell morphology is associated with Nodular-lymphocyte predominant Hodgkin Lymphoma?

Answer 11

popcorn” cell morphology.

Question 12

Clinical features of Nodular lymhocyte, hodkin lymphoma

Answer 12

Most patients are males in their 30s
Mostely peripheral lymph nodes involved
Mediastinal lymphadenopathy

Question 13

Define classical hodkin lymphoma

Answer 13

Comprises a heterogeneous group of lymphoid neoplasms derived from the geminal center

Question 14

What are the characteristics of classical hodkin lymphoma

Answer 14

1. Presence of relatively few diagnostic neoplastic cells, ree-sternberg cells, in rich background
   2.peaks between age 15 and 34 and older than 54 years

Question 15

Classical hodkin is divided into 4 subtypes based on architectural features. Mention them

Answer 15

1. Nodular sclerosis
2. Mixed cellularitu
3. Lymphocyte rich
4. Lymphocyte depleted

Question 16

What is burkitt lymphoma

Answer 16

Is a lymphatic solid tissue tumor composed of mature B lymphocytes with characteristics morphology called burkitt cells

Question 17

What is burkitt lymphoma

Answer 17

Is a lymphatic solid tissue tumor composed of mature B lymphocytes with characteristics morphology called burkitt cells

Question 18

What is sporadic burkitt lymphoma

Answer 18

rare, fast-growing cancer that primarily affects children and, less frequently, young adults.