TEST 1 . MULTIPLE CHOICE Flashcards
What virus causes lymphoid malignancies in humans
Epstein-Bar virus
Tumor suppresor genes causes cancers such as leukemia when mutations result in
Failure to prevent malignant process
what is a cellular abnormality produced by oncogenes
Acceleration of DNA catabolism
Oncogenes are said to act in a dominant fashion because
A mutation in a single allele is sufficient for malignancy to develop
Compared with autologous bone marrow transplantation, allogeneic transplantation has
better long term success
Chemotherapeutic agents are divided into which two major subgroups
phase specific
phase non specific
Qualitative and quantitative neutrophil changes noted in response to infection include
neutropenia
toxic granulation
vacuolization
The WHO classification requires what percentage for the blast count in the blood or bone
At least 20%
neutropenia is present in patients with which absolute count
<1.5*10^9/L
A m:e (myeloid:erythroid ration) of 10:1 is mostly seen in
Leukemia
In addition to morphology, cytochemistry, and immunophenotyping, the WHO classification of Myelo- and lymphoproliferative disorders is based upon which characteristic?
Cytogenetic abnormalities
Which AML cytogenetic abnormality is associated with acute myelomonocytic leukemia
with marrow eosinophilia under the WHO classification of AML with recurrent genetic
abnormalities?
AML with inv
Which of the following leukemias are included in the 2008 World Health Organization classification of myeloproliferative neoplasms?
Chronic myelogenous leukemia (CML)
Chronic neutrophilic leukemia (CNL)
Chronio eosinophilic leukemia (CEL)
Frequent phlebotomy in polycethemia vera patients may lead to
iron deficiency anaemia
in essential thrombocytopenia the platelets are
increased in number and fuctionality abnormal
Which of the following cells is considered pathognomonic for Hodgkin’s disease?
Reed- sternberg cells