TEST 1 SCIENTIFIC REASONING

Question 1

Higher dosages of Imatinib will restore remission in most patients who acquire
additional BCR/ABL during treatment of CML

Answer 1

This is because of the development of imatinib resistance which results in relapse due to the presence of BCR/ABL mutations. so when the dose is increased it increases remission

Question 2

Write a scientific reason for the occurrence, Clinical symptoms mimic those of acute leukemia in the Blastic phase of CML .

Answer 2

Because of rapid proliferation of immature cells which crowd the normal blood cells. This leads to bone marrow failure and deficiency in health blood cell

Question 2

Write a scientific reason for the occurrence of When performing differential counts and encountering a lymphocytic cell that
looks like a blast is most likely a reactive lymphocyte if all other findings are normal.

Answer 2

This can show that there is an infection in the peripheral blood and raises concern of leukemia