TEST FOR FIBRINOLYSIS

Question 1

What are the 2 types of fibrinolysis?

Answer 1

Primary fibrinolysis
Secondary fibrinolysis

Question 2

This type of fibrinolysis occurs naturally

Answer 2

Primary fibrinolysis

Question 3

In the primary fibrinolysis, after coagulation cascade, it will naturally _________?

Answer 3

Breakdown clot

Question 4

This type of fibrinolysis is due to an external cause.

Answer 4

Secondary fibrinolysis

Question 5

Give an example of secondary fibrinolysis

Answer 5

Medication, Trauma

Question 6

What will secondary fibrinolysis cause?

Answer 6

Excessive bleeding

Question 7

Enumerate the test for fibrinolysis

Answer 7

Euglobulin clot lysis time
Ethanol gelation time
Protamin sulfate test
D-dimer test

Question 8

What do the plasma euglobulin fraction contain?

Answer 8

Plasminogen
Activators of plasminogen and fibrinogen

Question 9

What is the principle of ECLT?

Answer 9

The plasma euglobulin is precipitated using 1% acetic acid

Question 10

Under ECLT, the precipitates are redissolved and clotted with _______?

Answer 10

Thrombin

Question 11

At what temperature is complete lysis measured in ECLT?

Answer 11

37°C

Question 12

What is the normal clot lysis time under ECLT?

Answer 12

2 - 4 hours

Question 14

What value under ECLT, is indicative of abnormal fibrinolytic activity?

Answer 14

<2 hours

Question 15

What does <2 hours indicate in ECLT?

Answer 15

Abnormal fibrinolytic activity

Question 16

Enumerate the causes of INCREASE FIBRINOLYSIS

Answer 16

Circulatory collapse
Adrenaline injection
Sudden death
Pulmonary surgery
Pyrogen reaction
Obstetric complication

Question 17

What value indicates “increase fibrinolysis”?

Answer 17

> 4 hours

Question 18

Who made the ethanol gelation test?

Answer 18

Breen and Tullis

Question 19

Ethanol gelation test and Protamine sulfate test are both used to detect what?

Answer 19

Presence of fibrin monomer in the plasma

Question 20

EGT and PST, are utilized as an aid in the diagnosis of?

Answer 20

Disseminated Intravascular Coagulation

Question 21

What reagent is added to the blood sample for a gel formation to be made under EGT and PST?

Answer 21

50% ethanol

Question 22

What is the positive result of the Ethanol Gelation Test and Protamine Sulfate Test?

Answer 22

Clotting or clot formation

Question 23

What is the negative result of EGT & PST?

Answer 23

No gel formation

Question 24

This is the most specific test for fibrin degradation products (FDP)

Answer 24

D-Dimer test

Question 25

What is the purpose of the D-dimer test?

Answer 25

To measure the fibrin formation

Question 26

D-D fragment arises from the?

Answer 26

Degradation of crosslinked fibrin

Question 27

What does the D-Dimer test use?

Answer 27

Latex beads with monoclonal Ab to D-dimer

Question 28

What is the normal value of the D-Dimer test?

Answer 28

<200 ng/mL

Question 29

Increased results of D-dimer test may be seen in patients with?

Answer 29

DIC Thrombosis Phlebitis

Question 30

These are present in secondary fibrinolysis and not in primary

Answer 30

FDP: D-Dimer, X, Y, D, E

Question 31

This is a test for fibrin split products (FSP)

Answer 31

Thrombo-wellcotest

Question 32

In throbo-wellcotest, the whole blood is added to __________ to ensure complex clotting and __________________.

Answer 32

Thrombin Soya bean enzyme inhibitor

Question 33

Under thrombo-wellcotest, after incubation, the patient's serum is incubated and diluted with?

Answer 33

Latex particles coated with anti-fibrin split products

Question 34

What is the positive result of thrombo-wellcotest?

Answer 34

Presence if agglutination