ACQUIRED DISORDERS OF COAGULATION

Question 1

If fresh plasma cannot correct the coagulation, it means that there is a presence of?

Answer 1

Inhibitors

Question 2

This is a non-specific inhibitor directed towards platelet phospholipid and phospholipid-protein complex

Answer 2

Lupus anticoagulant / Antiphospholipid Antibodies

Question 3

LA/APA is a non-specific inhibitor directed towards _______________ and ______________ complex?

Answer 3

platelet phospholipid
phospholipid-protein

Question 4

This are IgG autoantibodies directed against specific coagulation factors?

Answer 4

Specific factor inhibitors

Question 5

What is the coagulation result of LA/APA?

Answer 5

Prolongs APTT and dilute Rusell venom test

Question 6

Specific factor inhibitors can be detected only with the use of?

Answer 6

Factor assay

Question 7

Vitamin K deficiency will result in a functional decrease of factor?

Answer 7

10, 9, 7, 2, C, S, and Z

Question 8

What causes vitamin K deficiency?

Answer 8

Presence of vitamin K antagonist
Obstructive jaundice
Decreased absorption
Decreased of normal flora in the GIT

Question 9

Liver disease can decrease or destroy most of the coagulation factor except for?

Answer 9

Factor VIII and IV

Question 10

Under liver disease, the factor to be destroyed last is the?

Answer 10

Factor I

Question 11

Under liver disease, the factor to be destroyed first is the?

Answer 11

Factor VII and PK

Question 12

What is the coagulation test of liver disease?

Answer 12

PT and APTT are prolonged

Question 13

Enumerate the acquired disorders of coagulation

Answer 13

Inhibitors
Vitamin K deficiency
Liver disease
Massive transfusion
Disseminated Intravascular Coagulation (DIC)

Question 14

This is defined as the replacement of more than 1.5 mL of blood volume in 24 hours resulting in DILUTION of coagulation factors and increased production of anticoagulants

Answer 14

Massive transfusion

Question 16

Under massive transfusions, the replacement of 1.5 mL of blood volume in 24 hours will lead to?

Answer 16

Dilution of coagulation factors
Increased in anticoagulants

Question 17

By how much does blood transfusion increase anticoagulant?

Answer 17

10%

Question 18

This results from the liberation of thromboplastic substances that activates coagulation and fibrinolysis

Answer 18

DIC

Question 19

What is activated through the contact phase?

Answer 19

Plasminogen

Question 20

When plasminogen is activated through the contact phase, the coagulation and fibrinolysis will occur simultaneously, resulting in?

Answer 20

Consumption of coagulation factors and platelets
RBC fragmentation
Increased in FDP and FSP