Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > Test > Flashcards

Test Flashcards

1
Q

Low affinity IgM is effective at eliminating microorganisms because (compared to IgG)

A

IgG has 2 binding sites. IgM has 10 binding sites. Therefor, even with low affinity, it can still have high avidity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

B cell proliferation cytokines

A

IL-2, 4, 5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

IFN-y effect on B cell

A

Become plasma cell secreting IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

TGF-b effect on B cell

A

Become plasma cell secreting IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

IL-4 effect on B cell

A

Become plasma cell secreting IgE or IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

IL-2, 4, 5 effect on B cell

A

Become plasma cell secreting IgM for complement activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which Ig can transport across epithelium

A

IgA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Subclasses of different IgG have slightly different sequences where

A

In their H-Chains which results in the different functional activities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

IgG provides the bulk of immunity for

A

Blood born pathogens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

IgM and IgD- what happens when one binds an antigen while on B cell

A

B cell internalizes Ag, processes it and presents it to helper T cell. It then proliferates and differentiates into Ab secreting plasma cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

First antibody produced by Ag-activated B cell prior to contact with Th cell

A

IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Secretory component (SC) of IgA function

A

Involved in transepithelial transport of exocrine IgA and stabilizes IgA against degradation in the GI tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Secretory IgA function

A

Binds to antigens and prevents or inhibits their attachment to/or invasion of epithelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Hassals corpuscles are involved in

A

Generating T regulatory cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

White pulp is made up of

A

T and B cell zones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

IFN a/b have potent

A

Antiviral activities

17
Q

What triggers the expression of E and P selection on endothelial cells, and what synthesizes the molecules

A

E-Selectin- IL-1 and TNF, synthesized by mast cells and macrophages
P-Selectin- Histamine or thrombin trigger expression

18
Q

MCP-1 chemokine does what

A

Mediates recruitment of monocytes

19
Q

CD44 expressed where, binds what, and causes what

A

Expressed on T cells, binds E-selectin or HA on activated endothelial cells, causes increased integrin affinity (inside-out signaling)

20
Q

IL-12 effect and what produces it

A

Produced by macrophages, stimulates IFN-y production by NK cells and T cells

21
Q

IL-15 effect

A

Proliferation of NK cells

22
Q

IL-12 and TGF-b effect

A

Control of inflammation

23
Q

Which TLRs recognize extracellular pathogens

A

1, 2, 4, 5, 6

24
Q

Which TLRs recognize intracellular pathogens

A

3, 7, 8, 9

25
Q

What triggers inflammasome activation

A

Crystals, reduction in cytosolic K+, microbial products

26
Q

SR-AI and SR-AII mediate

A

The uptake of oxidized lipoproteins which leads to atherosclerosis

27
Q

SRs bind molecules based on

A

Negative charges

28
Q

Eukaryotic cell carbohydrates vs microbial carbs

A

Eukaryotic carbs are terminated by galactose and sialic acid.
Bacterial carbs are have mannose, n-acetylglucosamine and B-glucans

29
Q

DAMPs include

A

ATP, Lipid (oxLDL, saturated fatty acids) HSP, HMGB1

30
Q

Monocytes/macrophages begin arriving at sites of inflammation after how long

A

16-48 hours

31
Q

Defensins are produced by

A

Epithelial cells at mucosal surfaces, neutrophils, NK cells, CTLs

32
Q

Cathelecidins produced by

A

Neutrophils

33
Q

Cathelecidins function

A

Direct or indirect toxicity to microbes (can activate leukocytes)
Bind and neutralize LPS
Some can play anti-inflammatory role by binding DNA and blocking inflammasome activation

34
Q

Effect when natural killer cell releases IFN-y vs IL-10

A

If IFN-y is released, macrophages and T cell responses are boosted
If IL-10 is released, they are dampened

35
Q

Ligands MICA/MICB

A

Absent on healthy cells, expressed upon cellular stress associated with viral infection/malignant transformation
NK cells have NKG2D receptors that recognize MICA/MICB and activate them

36
Q

IL-1 secreted by, causes

A

Secreted by macrophages, activates endothelial cells, causes fever, synthesis of APPs by liver

37
Q

CRP and SAP

A

CRP- recognizes phosphorylcholine on bacteria
SAP- recognizes phosphatidylethanolamine on apoptotic cells

Both can activate complement system by binding C1q

Immunology (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions