test 4 Flashcards
• Heart wall
Epicardium
• Myocardium
• endocardium
Cardiac Skeleton (4 functions?)
• Lies between the atria and ventricles – Anchors the valves – Prevents over-dilation – Point of attachment (fibrous ring) – Blocks electrical signals
fasciae adherens
binds the ends of cells to allow the force of one cell to be transmitted to adjacent ones
blood supply to the heart
left and right coronary arteries get blood from aortic canal, goes into coronary arteries, into capillaries, aortic veins, into coronary sinus and then right atrium
Coronary Artery Disease
=not getting enough oxygen to heart muscle
- angina: mild, presents chest pain
- Myocardial infraction(heart attack): complete arterial blockage, cells begin to die because of lack of oxygen
Heart Failure
=progressive weakening of the heart as it fails to keep up with blood pumping and oxygen demands
– Congestive heart failure: heart enlarges while pumping efficiency declines
– Pulmonary hypertension: enlargement and sometimes ultimate failure of right ventricle resulting from elevated BP in pulmonary circuit
Arrhythmia
=variation from normal heart beat
-fibrillation: rapid, random firing of ventricular muscle (ventricular fibrillation) or of the AV node (atrial fibrillation)
after centrifugation of blood sample
top: plasma (less dense, 55% of whole blood)
Middle: buffy coat (leukocytes and platelets, <1% of whole blood)
Bottom: erythrocytes (most dense, 45% of whole blood)
*buffy coat + erythrocytes = formed elements
Plasma
- 90% water
- Ions (Na+, Cl-)
- Sugars
- Amino acids
- Waste (urea, ammonia, CO2)
- Oxygen
- Hormones
- proteins
3 plamsa proteins
• Albumin
– Keeps water from diffusing out of the vessels
• Globulins
– Antibodies
– Proteins to transport fat, iron and copper
• Fibrinogen
– Helps in blood clotting
Blood Cells
• Most are not true cells – Lack some components – Cannot divide • 3 groups of blood cells: – Erythrocytes – Leukocytes – Platelets
Erythrocytes
• Red blood cells • Most numerous • Biconcave shape for flexibility • No nuclei or organelles – Filled with hemoglobin to carry oxygen
Leukocytes
• White blood cells (complete cells) • Defense • Granulocytes: – Neutrophils – Eosinophils-> turn off allergic response, kill parasites – Basophils-> release histamine • Agranulocytes: – Lymphocytes – Monocytes
Platelets
- AKA Thrombocytes
- Clotting-create a mesh
- Adhere to exposed collagen at the site of the tear to seal it
Common among arteries and veins
• Tunica intima: superficial
- endothelium: smooth muscle
- subendothelial layer
- internal elastic layer (only in arteries, more stretch and recoil)
• Tunica media:
-changes the diameter, artery has elastic fibres
• Tunica externa:
-has collagen fibres, site of platelet attachment