Test 3 Flashcards
- Volume of distribution definition/equation
V= amount of drug in the body / concentration measured in plasma.
A hypothetical volume of body fluid that would be required to dissolve the total amount of drug needed to achieve the same concentration as that found in the blood.
- Cephalosporins:
Metabolism:
Elimination:
Legalities:
- Cephalosporins:
Metabolism: ONLY CEFTIOFUR IS METABOLIZED (ceftiofur is not active until metabolized).
Elimination: Most are eliminated by the kidney as the parent drug. Good for urinary tract infections.
Legalities: (excluding Cephapirin) Illegal for extralabel (except for EL purpose) use in cattle, swine, poultry
Drugs in 2nd Generation Cephalosporins
Cefoxitin
Drugs in 3rd Generation Cephalosporins
Cefotaxime
Ceftiofur
Cefpodoxime
Cefovecin
Drugs in 4th Generation Cephalosporins
Cefepime
Drugs in Group 7 Cephalosporins
Cefepime
Drugs in Group 5 Cephalosporins
Cefpodoxime
Drugs in Group 4 Cephalosporins
Cefotaxime
Ceftiofur
Cefovecin
Drugs in Group 3 Cephalosporins
Cefoxitin
Drugs in Group 2 Cephalosporins
Cephalexin
Drugs in Group 1 Cephalosporins
Cephapirin
Cefazolin
1st Generation Cephalosporins
MOA: AE: CI: Legal: What do they Treat?
MOA: Inhib cell wall synth
AE: Allergies, bleeding problems
CI: not for animals allergic to beta lac, rec. warfarin anticoag.
Legal: Cephapirin = withdrawal for milk/cattle
TX: Gram+,
cephapirin used for mastitis
2nd generation cephalosporins
MOA:
AE:
CI:
TX:
- MOA: inhib cell wall synth.
- AE: allergies, agg. bldg problems
- Not for animals allegic to beta lac./rec. warfarin anticoag.
- TX: enterobac, anaerobes
3rd generation cephalosporins
list them: MOA: AE: CI: TX: Legal:
List: Cefotaxime, Cefpodoxime, Ceftiofur, Cefovexin
MOA: inhib. cell wall synth
AE: allergies, agg. bldg problems
- Ceftiofur: BM suppression, thrombocytopenia, anemia, diarrhea in horses
- Cefovecin: vomit/dia in dogs/cats, inj. site irr. and edema, long half life at site of inj. GI upset
CI: allergies and warfarn normal but:
- Ceftiofur - don’t give IV, High doses, don’t combine formulations
TX: NOT Staph. aureus, pseudomonas, Gram - Anaerobes
Legal: Ceftiofur withdrawal, Cefovecin not for FA
4th Generation Cephalosporins
List them: MOA: AE: CI: TX:
List: Cefepime (grp7)
MOA: inhib. cell wall synth.
AE: allergies, bldg disorders, vomit/dia
CI: nor for Blactam allergic, reduce to less intervals w/patients w/renal failure
TX: Respiratory, Enterobacteriacea, Pseudomonas
Carpabenems
List them
Imipenem
Meropenem
Imipenem
MOA:
AE:
CI:
TX:
MOA: binds PBP-1 and weakens cell wall faster than other beta lactams
AE: allergies, rapid infusion = neurotox., nephrotox, vomit, nausea, IM painful
CI: use caution in animals prone to seizure. DRUG OF LAST RESORT.
TX: Everything (not mycoplasma, spirochetes)
Meropenem
MOA:
AE:
CI:
TX:
MOA: binds PBP-1 which weakens cell wall faster than other beta lactams
AE: less prone to seizures than imipenem, allergies, SQ injections may experience hair loss
CI: yellow discoloration when reconstituted, dark indicates loss of potency. DRUG OF LAST RESORT.
TX: Everything (not spyro or myco)
Metronidazole
- MOA:
- AE:
- CI:
- TX:
- Legal:
- MOA: reduced in anaerobic environment, (electron sink) to toxic intermediate.
- AE: CNS Toxicity via inhib. of GABA; mutagen, vomiting, anorexia, benzoic acid toxic to cats, Type II idiopathic
CI: caution w/seizure animals esp. w/renal failure
TX: Anaerobes, protozoa
legal: ILLEGAL FOR EXTRALABEL USE IN FA
Polymixins
MOA:
AE:
TX:
MOA: interfere w/bacterial cell membrane function, inhib. formation and prot. synth
AE: narrow therapeutic index, renal injury at long/high doses, hydrate or kidney dmg, doesn’t work w/puss/detergents
TX: Enterobacteriacea
Bacitracin
MOA:
AE:
TX:
MOA: interferes with bacterial cell membrane function.
AE: Nephrotox, hypersens. rxns
TX: most Gram -
Nitrofurans
MOA: AE: CI: TX: Legal:
MOA: Urinary antiseptic, thera conc. reached only in urine, inhib. bac. DNA/RNA
AE: naus, vomit, dia, urine turns rust yellow/brwn,
CI: not while prego, can cause hemoly. anemia in newborn, not for neonates
TX: UTI’s
Legal: Illegal in FA
Rifampin
MOA:
AE:
TX:
MOA: inh. bac. RNA synth
lipid sol. can enter cells and conc. in leuko to inhib intracell. bac.; complexes w/beta subunit of DNA dependant RNA polymerase to inactivate it.
AE: people - hypersens/flu like symptoms
- hepatotox in dogs, elevated liver enzymes, urine orange to red/organge, may discolor saliva, teaers, feces, sclera and mucousm., ubpalatable, pancreatitis
- INDUCES CytP450 so may increase met. of other drugs
TX: Gram+, used w/macrolides
Amphoteracin B
Class of Drug: MOA: AE: CI: Effect:
CoD: Antifungal
MOA: binds to ergosterol in cell membrane causing loss of integrity, leaking, cell death
AE: Dose dep. nephrotox., fever phlebitis, tremors, renal potassium wasting, CHECK FOR CASTS, BUN, CREATINE, Nyastatin - PU/PD, V/D
CI: NOT FOR PTNTS W/RENAL DZ OR IN DEHYDRATED
Effect: fungicidal drug for systemic fungi, some protozoa
Caspofungin
MOA;
AE:
CI:
Effect:
MOA: inhib. Glucan in fungal cell wall; inhib. cell wall synth
AE: hepatic sens, GI symptoms, increased liver enzymes
CI: acts w/cyclosp. cause elevated liver enz and tacrolimus
Effect: Fungicidal
Flucytosine
MOA:
AE:
CI:
Effect:
MOA: converted to flurorouracil, acts as antimetabolite, pen. fungal cell wall
AE: anemia, thrombocytopenia, cutaneous and mucocutaneous eruptions in dogs
CI: Not for dogs
Effect: tx cryptococcal meningitis often in combo w/Amphoteracin
Griseofulvin
Class of drug: MOA: AE: CI: TX: Legal:
Class: Antifungal
MOA: inhib mitosis of fungal cells, kills them
AE: teratogen, anemia, leukopenia, anorexia, depression, v/d, FIV-marrow toxicosis w/irrevers. pancytopenia
CI: not for prego cats, caution if have FIV
TX: DOC for systemic dermatophyte treatment
Legal: not for for FA as it’s teratogenic
Terbinafine
COD: MOA: AE: CI: TX
COD: Allylamin antifungal
MOA: targets squalene epoxidase to inhibit ergosterol synth.
AE: Vomit, nausea, anorexia, increased liver enzymes, facial puritis, hapatotoxic
CI: none; note, stays longer in hair than does systemic
TX: used for dermatophyte and Malazzezia yeast infections
Flucanoazole
COD: MOA: AE: CI: TX: Legal:
COD: Azole antifungal
MOA: inhib ergosterol synth. in cell membrane
AE: hepatopathy, increased liver enzyme, endocrine dysfunction
CI: caution in prego animals, fetal abnormalities in lab animals
TX: works on dermatophytes, systemic fungi and yeasts (candida, coccidiodes and cryptococcus)
Legal: none
Itraconazole
COD: MOA: AE: CI: TX:
COD: Azole antifungal
MOA: inhib ergosterol synth. in cell membrane
AE: hepatotoxicity, INC. LIVER ENZYMES, NO endocrine dysf., vaculitis and skin lesions in dogs, vomiting in cats, anemia
CI: caution w/liver dz and prego, fetal abnormalities in lab animals.
TX: works on dermatophytes, systemic fungi, blastomyces, histoplasma, coccidiodes
ketoconazole
COD: MOA: AE: CI: TX: Legal:
COD: Azole antifungal
MOA: inhib ergosterol synth. in cell membrane, INHIBITS CYT. P450 enzyme in fungi
AE: hepatotox, increased liver enzyes, endocrine dys., low cortisol and testosterone, V/D, hepatic injury, lighter hair, cataracts, lower hormone synthesis
CI: not for prego, embryotoxic and fetal abnormalities in lab animals
TX: works on dermatophytes, systemic fungi and histoplasma, blastomyces, coccidiodes, malassezia
Legal: NA
Posaconazole
COD MOA AE CI TX Legal
COD: Azole antifungal
MOA: inhib ergosterol synth. in cell membrane
AE: headache, diarrhea, nausea, increased liver enzymes, neuronal vacuolation
CI: not prego, lab abnormalities
TX: works on dermatophytes, systemic fungi and yeasts (as do all azoles)
Legal: NA
Voriconazole
COD: MOA AE CI TX Legal
COD: Azole antifungal
MOA: inhib ergosterol synth. in cell membrane (prev. P450 enzyme)
AE: neurotox in cats, vomit, hepatotox, ocular problems in ppl; CNS signs that resolve after disuse
CI: prego, lab animal abnormal., use PO form in animals with renal issues
TX: works on dermatophytes, systemic fungi, yeasts
Miconazole
used for:
Class of drug:
OTC topical (vag cream) COD: antifungal
Nystatin
how administered:
MOA:
AE:
CI:
- Topical only
- MOA: binds ergosterol in cell membrane causing leaking, cell death
- AE: NEPHROTOXIC, fever, phlebitis, tremors, renal K wasting, PU/PD, V/D
- CI: not for ptnts w/renal dz or dehydrated animals
Drugs in 1st Generation Cephalosporins
- Cefazolin
- Cephapirin
- Cefalexin
assume these adverse effects with all of the -azole antifungals
- Increased liver enzymes
- possible liver disease (hepatopathy)
- inhibit P450 enzyme
Bethanechol
Class of Drug: Effect: MOA: AE: CI:
- COD: Promote Urination
- Effect: Muscarinic Cholinergic agonist
- MOA: stimulates gastric/intestinal motility and contraction of urinary bladder ; resists acetylcholinesterase
- AE: Increase GI mot resulting in diarrhea, circulatory depression
- CI: not w/obstruction
Phenoxybenzamine
- Class of Drug:
- Effect:
- MOA:
- AE:
- CI:
- COD: Promote urination
- Effect: adrenergic antagonist (relax urethral sm. mm), vasodilator
- MOA: alpha 1 antagonist
- AE: hypotension, tachycardia, weakness, syncope, diarrhea in horses
- CI: not with heart problems, not if dehydrated
Phenylpropanolamine
COD: Effect: MOA: AE: CI:
COD: Reduce incontinence
Effect: adrenergic agonist (const. sm. mm)
MOA: nonselective adrenergic agonist (A&B)
AE: tachycardia, cardiac effects, CNS excitement, restlessness, appetite stimulation, increased BP, stroke
CI: not with cardiovasc. dz
Diethylstilbestrol
COD: Effect: MOA: AE: CI:
COD: reducing incontinence
Effect: synthetic estrogen
MOA: synth estrogen, increases sens. of alpha receptors in urinary sphincter
AE: increased risk of pyometra, estrogen sens. tumors, rarely bone marrow depression and anemia
CI: risk of cancer in humans
Estriol
COD: Effect: MOA: AE: CI:
COD: Reduce Incontinence Effect: estrogen hormone MOA: estrogen, increases sens. to alpha 1 receptors in urinary sphincter AE: NONE CI: not for prego animals or FERRETS
Ammonium Chloride
COD: Effect: MOA: AE: CI:
COD: Reduce urinary calculi
Effect: urine acidifier (manages crystal calc. and chronit UTI’s)
MOA: induces acidic urine
AE: bitter taste in food, aacidemia in high doses
CI: not w/systemic acidemia or renal dz
Potassium Citrate
COD: Effect: MOA: AE: CI:
- COD: reduce urinary calculi
- Effect: urine alkalinizer (brks up urinary calculi)
- MOA: alkalinizes urine and increases urine citric acid which decreases urinary calcium oxalate crystallization
- AE: toxicity, hyperkalemia leading to cardiovasc tox., muscular weakness, nausea, stomach irritation
- CI: renal dz, not with other K drugs
Acronym for Diuretics:
FMASH
F - Furosemide M - Mannitol A - Acetazolamide S - Spiranolactone H - Hydrochlorothiazide
Acetazolamide
Effect: COD: MOA: AE: CI:
- COD: Diuretic
- Effect: Carbonic anhydrase inhibitor diuretic (used to lower intra-ocular pressure)
- MOA: carbonic anhydrase inhibitor; inhibits uptake of bicarb in PROXIMAL renal tubule, which resuts in loss of bicarb, water, and alkaline urine
- AE:hypokalemia, bicarb loss, REP RXN due to RESP ACIDOSIS
- CI: not w/acidemia or those sensitive to sulfonamides
Mannitol
COD: Effect: MOA: AE: CI:
- COD: Diuretic
- Effect: osmotic Diuretic (increases osm. of plasm that dec. edema, intracranial and intra-ocular pressures)
- MOA: filtered in glomerulus (PROX TUBULE, LOH) but not reabsorbed, increases osmolarity of urine, leads to inhibition of reabsorption
- AE: fluid loss, electrolyte imbalance, rapid infusion = excessive ECF expansion
- CI: not dehydrated or w/intracranial bldg
Furosemide
COD: Effect: MOA: AE: CI:
- COD: Diuretic
- Effect: Loop Diuretic (used for edema)
- MOA: Na/K/Cl symporter inhibitor
- AE: hyponatremia more common than hypokalemia in dogs, tolerance and activation of RAAS with repeated admin.
- CI: caution w/RAAS inhib. to decrease risk of azotemia (elev. BUN/cr)
Hydrochlorothiazide
COD: Effect: MOA: AE: CI:
- COD: Diuretic
- Effect: thiazide diuretic (decrease Na and water reabsorption, not a strong diuretic as occurs so late in the process)
- MOA: inhibits Na reabsorption in DISTAL TUBULE (incr. Na, K and Water, decreases Ca excretion)
- AE: Hypokalemia
- CI: not w/high serum calcium (prevents Ca excretion)
Spironolactone
COD: Effect: MOA: AE: CI:
- COD: Diuretic
- Effect: Aldosterone antagonist diuretic
- MOA: potassium sparing diuretic, inhib. aldosterone; interferes w/ Na reabsorption in DISTAL TUBULE
- AE: hyperkalemia, high doses have steroid like effects, facial dermatitis in cats
- CI: not if dehydrated, Gi problems, NSAIDS interfere, don’t give w/K supp.
Most Diuretics cause K to be high or low?
Low (all but Spironolactone)
put these in order of importance when using diuretics:
Hyponatremia, Dehydration, Hypokalemia
- Dehydration
- Hypokalemia
- Hyponatremia
most common alteration in patients relating to fluid balance:
- acid/base imbalance
- electrolyte imbalance
- water imbalance (dehydration, Hypovolemia)
- hypoproteinemia
Therapeutic Goals for fluid therapy alterations:
water imbalance
hypoproteinemia
electrolyte imbalance, etc.
- Improve tissue perfusion by replacing intravascular volume
- meet maintenance needs
- correct dehydration by replacing interstitial volume
- replace on going losses
Water accounts for what % of total body weight?
ECF ICF Blood Plasma Interstitial
Water: 60%
ECF: 20% Plasma: 5% of ECF interstitial: 15% of ECF ICF: 40% Blood: 7% of ICF
what’s Higher in ECF vs. ICF
Na
K
Cl
Ca
Inside:
- K
Outside:
- Na
- Cl
- Ca
Drug (fluid therapy) options less commonly used for physio alterations resulting in the need for use of therapy include:
- hemoglobin based oxygen carrying compounds
- blood products
- parenteral nutrition
drug (fluid therapy) options most commonly used for physio alterations resulting in fluid therapy:
colloids
crystalloids
main difference between maintenance and replacement crystalloid fluids:
Na concentration
Lesser importance: generally higher conc of K in maintenance
maintenance fluids have Na content that resembles:
ECF or ICF
Replacement fluid Na conc resembles ECF conc of Na
ICF, Na is lower.
replacement fluids would be higher in Na while Maintenance fluids would be lower in Na
what % remains in the IV space after 1 hour?
- Replacement Crystalloids
- Maintenance Crystalloids
If concerned about volume, what should you do? (not answered on card)
- Replacement: 25%
- Maintenance: 10%
Commonly used colloids:
distinguishing characteristic of colloids from crystalloids?
- plasma
- albumen
- synthetic colloids
- oncotic (colloid osmotic properties)
parameters to be monitored during fluid therapy:
- normal bronchiovesicular lung sounds (pulm. edema w/fluids)
- PCV (diluted w/fluids)
- total protein (decreases)
- electrolytes (change)
- arterial pH
- arterial pCO2
- Urine Output (increase)
- Hemodynamics (hypervolemia)
Fluids that contain Mg:
Plasma Lyte-M
Plasma Lyte-A
Normosol M
Normosol R
Fluids that contain Calcium:
- Lactated Ringers
- Ringers
- Plasma Lyte M
Replacement Fluids
which are acidic
Which are alkalinic
Acidic: - ringers - Normal Saline Alkalinic: - Lactated Ringers - Normosol R - Plasma Lyte-A
Maintenance fluids:
List them
Are they acidic or alkalinic
- Normosol M
- Plasma Lyte-M
- Acid
Volume increasing fluids:
List them:
- Hypertonic Saline
- Hetastarch
Hetastarch
COD: Therapeutic Goal: MOA: AE: CI:
- COD: Fluids
- TG: decrease dehydration, correct hypovolemia (expander circ. shock)
- MOA: Colloid-like, expander; maint. vascular volume w/circulatory shock (synthetic starch molecule)
- AE: allergic rxn, hyperosmotic renal dysfunction, dec function of platelets
- CI: not for bldg patients, or coagulopathies
Hypertonic Saline (7.5%)
COD: Therapeutic Goal: MOA/contains: AE: CI:
COD: Fluids
TG: decrease dehydration, increase vascular volume/ correct hypovolemia, increase electrolytes (only Na and Cl)
MOA: Creates an osmotic gradient in the vascular space by high concentrations of Na and Cl to pull water from the ICF and interstitial spaces into the vascular space
Contains: Na, Cl
AE: long term infusion can lead to electrolyte imbalance
CI: hypernatremic or renal insufficiency; hyperosmolality can result
Lactated Ringers
COD: Therapeutic Goal: MOA: Contains: AE: CI:
COD: Fluids
TG: dec. dehydration, correct hypovolemia, increase electrolytes and increase alkalinity
MOA: replacement fluid (see above)
Contains: alkalinizing BES - Na, K, Cl, Ca
AE/CI: none
normal saline (.9%)
COD: Therapeutic goal: MOA: Contains: AE: CI:
COD: Fluids
TG: dec. dehy and/or hypovol, increase electrolytes
MOA: replacement fluid
Contains: acidifying BES - Na, Cl
AE: long term may cause electrolyte imbalance, acidema due to bicarb loss, hypokalemia
CI: none
Normosol - R
COD: Therapeutic Goal: MOA: Contains: AE: CI:
COD: Fluids
TG: dec. dehy and/or hypovol. increase electrolytes.
MOA: replacement fluid
contains: alkalinizing BES - Na, K, CL, Mg
AE/CI: None
Caution: congestive heart failure, renal insufficiency, edema, Na retention
Plasma-Lyte A
COD: Therapeutic goal: MOA: contains: AE: CI:
COD: Fluids
TG: dec. dehy, or hypovol, inc. electrol.
MOA: replacement fluid
contains: alkalinizing BES - Na, K, Cl, Mg
AE/CI: None
Ringers
COD: Therapeutic goal: MOA: Contains: AE: CI:
- COD: Fluids
- TG: dec. dehy, or hypovol., inc. electorlytes
- MOA: Replacement fluid
- Contains: acidifying BES - Na, K, Cl, Ca
- AE: inc acidity of blood due to inc. renal excretion of bicarb after prolonged use
- CI: don’t exceed 80ml/kg/hr - consider supp. w/K
Plasma-Lyte M
COD: Therapeutic Goal: MOA: Contains: AE: CI:
COD: Fluids TG: dec. dehy and/or hypovol, inc. electrolytes MOA: maintenance fluid contains: acidifying - Na, K, Cl, Ca, Mg AE/CI: None
Normosol - M
COD: Therapeutic Goal: MOA: Contains: AE: CI:
COD: Fluids TG: dec. dehyd, or hypovol. increase electorlytes MOA: maintenance fluid Contains: acidifying - Na, K, Cl, Mg AE/CI: None
List the Depolarizing and non-depolarizing drugs that induce muscle paralysis:
Depolarizing: - Succinylcholine Non-Depolarizing: - Atracurium - Cisatracurium - Pancuronium
Atracurium
COD: Effect: MOA: AE: CI:
- COD: muscle parlaytic
- Effect: Neuromuscular blocking agent - nondepolarizing, used to inhibit mm contractions
- MOA: Competes w/acetylcholine at the neuromuscular end plate
- AE: Produces resp. depression and parlaysis, no analgesic (pain) effect
- CI: dont admin. w/out Ventilation, will be antag. by ACh-ases, don’t give w/aminoglycosides b/c of potentiated NMB
Note: Circulates in Plasma, shorter duration than Pancuronium
Cisatracurium
COD: Effect: MOA: AE: CI:
- COD: Muscle paralytic
- Effect: neuromuscular blocking agent - nondepolarizing, used to inhib. mm contractions
- MOA: competes w/acetylcholine at the neuromuscular end plate
- AE: produces resp. depression and paralysis, no analgesic effect
- CI: don’t admin w/out ventilation, will be antag. by ACh-ases, don’t give w/aminoglycosides b/c of potentiated NMB
Pancuronium
COD: Effect: MOA: AE: CI:
- COD: Muscle paralytic
- Effect: neuromuscular blocking agent - nondepolarizing, used to inhib. mm contractions
- MOA: competes w/acetylcholine at the neuromuscular end plate
- AE: produces resp. depression and paralysis, no analgesic effect
- CI: don’t admin w/out ventilation, will be antag. by ACh-ases, don’t give w/aminoglycosides b/c of potentiated NMB
Note: METABOLIZED IN LIVER, EXC. THROUGH KIDNEY
Succinylcholine
COD: Effect: MOA: AE: CI:
- COD: Muscle Paralytic
- Effect: Depolarizing Neuromuscular blocking agent (BAD)
- MOA: binds to receptor, depolarizes it, stays and continues to block
- AE: DEATH
- CI:
Muscle Paralytic Drugs:
- Atracurium
- Cisatracurium
- Pancuronium
- Succinylcholine
Saying for mm relaxants:
Go : Guafenesin Find: Flumazenil My: Midazolam Lazy: Lorazopam Dog: Diazepam
Muscle relaxant drugs
- diazepam
- midazolam
- lorazepam
- flumazenil
- Guaifenesin
Diazepam
COD: Effect: MOA: AE: CI: Note:
- COD: mm relaxant
- Effect: anticonvulsant - benzodiazepine
- MOA: ativates GABA receptors, increasing CI conductance leading to hyperpolarization; not water soluble
- AE: sedation; dogs: ataxia, excitement, agitation, increased appetite; cats: fatal hepatic necrosis; withdrawal when stopped
- CI: not w/impaired liver function or long term use in cats
- NOTE: Not water soluble, withdrawal once removed
Midazolam
COD: Effect: MOA: AE: CI: Note:
- COD: muscle relaxant
- Effect: anticonvulsant - benzodiazepine
- MOA: activates GABA receptors increasing Cl conductance, hyperpolarization, water soluble
- AE: IV can cause cardioresp. depression, paradoxial excitement, withdrawal syndromes when discontinued
- CI: caution IV, esp. w/opiates
- Note: water soluble
Lorazepam
COD: Effect: MOA: AE: CI:
- COD: MM relaxant
- Effect: anticonvulsant - benzodiazepine
- MOA: activates GABA receptors increasing Cl conductance - hyperpolarization
- AE: sedation, polyphagia, excitement, withdrawal syndrome
- CI: liver injury in cats
Guaifenesin
COD: Effect: MOA: AE: CI: therapeutic goal:
- COD: mm relaxant
- Effect: expecorant mm relaxant (stim. vagal trans.)
- MOA: centrally reduces nerve transmission
- PO: stimulates vagal transmission for more viscous bronchiol secretions
- IV: centrally acting mm relaxant - AE: thrombophlebitis from IV, hypotension, hemolysis
- CI: don’t give IV if precipitated; don’t use human oral formulations
THERAPEUTIC GOAL: increase mm relaxation
Flumazenil
COD: Effect: MOA: AE: CI:
COD: mm relaxant
Effect: antidote - benzodiazepine receptor antagonist
MOA: blocks action of benzodiazopines on GABA receptors
AE: none
CI: may precipitate seizures (high first pass effect)
Estradiol
MOA:
AE:
CI:
MOA: estrogen replacement, also used to induce abortion AE: - endometrial hyperplasia - pyometra - bone marrow toxicity - leukopenia - thrombocytopenia - fatal aplastic anemia CI: not in prego animals, not for ferrets
Edrophonium
COD: MOA: AE: Effect: CI:
COD: Counteract neuromuscular blockade
MOA: anticholinesterase
AE: Salivation, Vomiting, diarrhea
Effect: Antimyasthenic, anticholinesterase; short lasting effects good for dx
CI: cats sens.; caution w/other cholinergic drugs
Neostigmine
COD: MOA: AE: CI: Use:
COD: counteract neuromusc. blockade
MOA: anticholinesterase, Ach isn’t broken down
AE: Diarrhea, increased secretions, miosis, bradycardia, mm twitching, weakness, constriction of bronchi and ureters
CI: not w/urinary or intestinal obstruction, asthma or bronchoconstriction, pneumonia, cardiac arrhythmias
Use: tx or myasthenia gravis, ileus and NM blockade
physostigmine
COD: MOA: AE: Effect: CI:
COD: counteract neuromuscular blockade
MOA: anticholinesterase, X’s BBB
AE: diarrhea, increased secretions, miosis, bradycardia, mm twitching, weakness, constriction of bronchi and ureters
Effect: prokinetic; anticholinesterase - treating myesthenia gravis, ileus, NM blockade
CI: not w/choline esters like bethanechol
Progesterone
therapeutic goal: See notes to update:
increases production of somatotropin, IGF1 (growth factor) which increases mm mass - implant in ear
Testosterone
What do they do:
Therapeutic goal:
and trenbalone: work directly (unlike progesterone and estradiol) to increase mm mass. Implant in ear
Therapeutic goal: increase muscle mass
trenbolone
Therapeutic goal - see ppt for more to put here
increase mm mass
epinephrine
COD: MOA: AE EFFECT: CI:
COD: increase cardiac contractions/Heart Rate
MOA: alpha1, b adrenergic receptor agonist (very potent, prompt onset, short duration)
AE: excessive vasoconstriction, hypertension, ventricular arrhythmias
Effect: tx for cradiopulmonary arrest and anaphylactic shock
CI: avoid repeat admin, incompatible w/alkaline solutions and salts
Isoproterenol
COD: MOA: AE: Effect: CI:
COD: increase force of cardiac contractions/heart rate
MOA: b adrenergic agonist (stim. adenyl cyclase, more pot. than epi)
AE: tachycardia, tachyarrhthymias, myocardial calcium accum, K imbalance
Effect: adrenergic agonist - increases HR, conduction, contractility of cardiac mm
CI: if formulation is pink/dark be careful; caution w. arrhthmogenic drugs
Dopamine
COD: MOA: AE: Effect: CI:
COD: inc. force of cardiac contractions and HR
MOA:
- precursor to norepinephrine (low doses incr. GFR)
- moderate doses (chronotropy and ionotropy)
- high dose (alpha 1 agonist - vasoconstriction)
AE: high dose sens. patients: tachycardia and etricular arrhythmias
Effect: adrenergic agonist
CI: unstable in alkaline fluids
dobutamine
COD: MOA: AE: Effect: CI:
COD: incr. force of cardiac contractions and HR
MOA: B agonist (favors B1) - mixed agonist and antagonist effect on alpha receptors
AE: tachycardia, ventricular arrhythmias at high dose in sens. patients
Effect:adrenergic agonist
CI: not w/ventricular arrythmias, alkaline solutions or IV w/heparin, cephalosporins or penicillins
Digoxin
COD: MOA: AE: Effect: CI:
COD: increase force of cardiac contractions
MOA: inactivates Na-K ATPase and increases intracellular Ca (increased contractility, decreased HR by baroreceptors)
AE: narrow therapeutic index, arrhythmia, vomiting, anorexia, diarrhea, all potentiated by hypokalemia
Effect:Cardiac inotropic agent
CI: dobermans and cats sens, high K diminishes effect
Pimobendan
COD: MOA: AE: Effect: CI:
COD: increase contractility and vasodilation
MOA: vasodilation via inhibition of phosphodiesterase 3 to increase cAMP - also is a CA SENSITIZER increasing interaction w/troponin C w/contractile proteins
AE: Arrhythmogenic, doesn’t activate RAAS at some doses
Effect: cardiac inotropic agent
CI: animals prone to arrythmias
Atropine
COD: MOA: AE: Effect: CI:
COD: incr. contractility and HR
MOA: acetylcholine antagonist - blocks Ach effects at Muscarinic receptors
AE: xerostomia (dry mouth), ileus, constipation, tachycardia, urine retention
Effect: muscarinic blocker
CI: not w/glaucoma, ileus, gastroparesis, tachycardia, use w/O2
Glycopyrrolate
COD: MOA: AE: Effect; CI:
COD: incr. contractility and HR
MOA: acetylcholine antagonist - blocks Ach effects at muscarinic receptors
AE: xerostomia (dry mouth), ileus, constipation, tachycardia, urine retention
Effect: muscarinic blocker
CI: not for patients w/glaucoma, ileus, gastroparessis, or tachycardia
Hydralazine
COD: MOA: AE: Effect: CI:
COD: vasodilation MOA: - relaxes sm. mm - reduces BP and vascular resistance - decreases afterload AE: vasodilation, hypotension, tachycardia, dangerous high cardiac output, triggers RAAS Effect: vasodilator CI: not w/hypotensive animals
Diltiazem
COD: MOA: AE: Effect: CI:
COD: vasodilation
MOA: Ca channel blocker
AE: hypotension, myocardial depression, bradycardia, AV block, cats GI
Effect:antiarrythmic and vasodilator - , neg. chronotropy/inotropy
CI: caution IV, not hypotensive patients w/furosemide
Amlodipine
COD: MOA: AE: Effect: CI:
COD: vasodilation
MOA: Ca channel blocker - dec. Ca influx in cardiac and sm mm, vasodilates
AE: hypotension, bradycardia, dogs: gingival hyperplasia
Effect: Ca channel blocker
CI: not for cardiac or hypotensive patients or dehydrated
Carvedilol
COD: MOA: AE: Effect: CI:
COD: vasodilator
MOA: B blocker, some alpha blocking
AE: bradycardia, myocardial depression and decreased CO
Effect: Antiarrhythmic, vasodilator
CI: not for cardiac, dehydrated, or hypotensive; caution in respiratory cases
Benazepril
COD: MOA: AE: Effect: CI:
COD: Vasodilator
MOA: ACE inhibitor: inhibits conversion of angiotensin I to angiotensin II - causes vasodilation and Na/H20 retention since all stimulate aldosterone
AE: azotemia, monitor renal values
effect:Vasodilator, ACE inhibitor - tx chronic heart failure and hypertension
CI: not for prego, ACE inhb. cross placenta - teratogen
Phenylephrine
COD: MOA: AE: Effect: CI;
COD: vasoconstriction
MOA: a1 receptor agonist, causes vascular sm. mm contraction
AE: prolonged peripheral vasoconstr., reflex bradcardia, prolonged topical use results in tissue inflammation
Effect: vasopressor - used to constrict superficial vessels
CI: not if compromised cariocascular status
acronym for decreasing sympathetic output:
BE CAP’T
- Benazapril
- Enalapril
- Carvedilol
- Atenolol
- Propanolol
- Timolol
Dopamine
COD: MOA: AE: Effect: CI:
COD: vasoconstriction
MOA:
- precursor to norepi: low doses - increases GFR
- moderate doses: chronotropy and inotropy
- high doses: a1 agonist - vasoconstriction
AE: sens. patients cuases tachycardia and ventricular arrhythmias
Effect: adrenergic agonist
CI: unsatble in alkaline fluids
Atenolol
COD: MOA: AE: Effect: CI:
COD: Decrease symp. effects
MOA: B1 receptor antagonist (B blocker) - relies on kidneys for clearance
AE: bradycardia, heart block, bronchospasm
Effect: Beta antagonist - decrease HR, cardiac conduction, BP, control tacharrhythmias
CI: caution w/airway and cardiac disease
Propranolol
COD: MOA: AE: Effect: CI:
COD: decr. symp effects
MOA: Unselective (B1 and B2), lipophilic B blocker
AE:
- B1: cardiac compression, decreased CO
- B2: broncho-constriction, decreased insulin production
Effect: beta antagonist (decrease HR, cariac conduction, BP control tacharrhythmias)
CI: not w/poor cardiac or systolic function or resp. problems
Timolol
COD: MOA: AE: Effect: CI:
COD: Decr. symp. effects
MOA: lipophilic, non-selective B blocker (dbl check ppt)
AE:
- B1: cardiac depression, decreased CO
- B2: broncho-constriction, decreased insulin production
Effect: beta antagonist (decr. HR, cardiac conduction, BP , control tacharrhythmias)
CI: not w/poor cardiac, systolic fxn, or resp. problems, used w/optholmic issues
Benazepril
COD: MOA: AE: Effect: CI:
COD: decr. symp. effects
MOA: ACE inhibitor (inhib. angiotensin 1-2, Angio II is vasoconstrictor, decreases aldosterone which dec. Na/H20 retention
AE: azotemia
Effect: vasodilator, ACE inhibotor, treats chronic heart failure and hypertension
CI: not for prego, ACE inhib. cross placenta and are teratogens
Enalapril
COD: MOA: AE: Effect: CI:
COD: decr. symp effects
MOA: ACE inhibitor (decrease aldosterone, so lower Na/H20 retention)
AE: azotemia
Effect: vasodilation, ACE inhibitor
CI: not prego, ACE inhib. cross placenta and is a teratogen
Aspirin
COD: MOA: AE: Effect: CI:
COD: anticoagulant
MOA: binds irreversibly to COX enzymes- more specific to cox1 at lower doses
AE: vomiting, increased risk of bldg and ulcers
Effect: analgesic, anti-inflammatory, anti-platelet drug
CI: cats susc. to intox. since slow clearance, not w/coagulopathies, not for those prone to ulcers
Clopidogrel
COD: MOA: AE: Effect: CI:
COD: anticoagulant MOA: inhib. ADP receptor mediated platelet activity AE: Bldg in susc. patients Effect: anti-platelet drug CI: not for those prone to bldg
Dalteparin
COD: MOA: AE: Effect: CI:
COD: Anticoagulant MOA: low weight molecular heparin AE: bldg in susceptible patients Effect: Anti-coagulant drug CI: renal dz will prolong clearance
Amiodarone
COD: MOA: AE: Effect; CI: carvedilol, diltiazem, lidocaine, procainamide, qunidine, sotalol
COD: Class 3
MOA: prolong AP duration by blocking K channels thus prolonging time before myocardial cells can contract again.
AE: dec appetite, bradycardia, AV block, CHF, hypotension, thyroid dysfunction, pulmonary fibrosis, neutropenia, anemia, hepatopathy (dog), lethargy, vomiting, puritis, edema, hindlimb weakness (horses)
Effect: fix V arrythmias
CI: caution in dogs, only use if its the only option
Carvedilol
COD: MOA: AE: Effect; CI:
COD: Class 2
MOA: Non-specific beta blocker (slow heart rate) with some alpha blocking (vasodilation)
AE: Bradycardia, myocardial depression, dec CO, other effects related to beta blocking in other tissues (bronchioles)
Effect: Fix arrythmias
CI: Dehydrated, hypotension. Caution: respiratory dz, limited cardiac reserve.
Diltiazem
COD: MOA: AE: Effect; CI:
COD: Class 2 beta blockers
MOA: Blocks Ca entry into the cells via voltage gated slow Ca channels causing negative chronotropic and neg ionotropic effects with some vasodilation.
AE: Hypotension, bradycardia, myocardial depression, AV block, anorexia, vomiting, lethargy
Effect; Fix supraventricular arrythmias
CI: hypotension, rapid IV injections
Lidocaine
COD: MOA: AE: Effect; CI:
COD: Class 1 local anesthetis/membrane stabalizer
MOA: Among other things it decreases phase 0 depolarization
AE: CNS effects, vomiting. Cats: death, dec CO, cardiovascular depression, dec purfusion, methemoglobinemia, hemolysis
Effect: Fix V arrythmias
CI: None
Quinidine
COD: MOA: AE: Effect; CI:
COD: Class 1 local anesthetis/membrane stabalizer
MOA: block Na channels to inhibit Na influx thus suppressing phase 0 action potential
AE: Nausea, vomiting , hypotension, tackycardia, sudden cardiac death (horses)
Effect: Fix atrial fibrilation
CI: caution in heart dz
Sotalol
COD: MOA: AE: Effect; CI:
COD: Class 2 and 3
MOA: nonspecific beta blocker and blocks K channel thus causing a longer refractory period
AE: Cardiac depression, dec CO, bronchoconstriction low insulin, weakness, proarrhthmic activity, neg inotropy
Effect:
CI: Caution in heart failure and AV block
Procainamide
COD: MOA: AE: Effect; CI:
COD: Class 1
MOA: Blocks Na channels to prevent Na influx
AE: cardiac arrhythmias, cardiac depression, tachycardia, hypotension
Effect;
CI: Proarrhthmic effects, dont use with digoxin
Which drugs specifically cause bronchiole dilation.
which drugs CAN cause bronchiole dilation (not main fxn)
DO:
- Albuterol
- Clebuterol
CAN:
- Epinepherine
- Isoproterenol
- Dopamine
- Dobutamine
Albuterol
COD: MOA: AE: Effect: CI:
- COD: bronchiole dilator
- MOA: B2 agonist (also inhib. inflamm. mediators from mast cells)
- AE: tachycardia
- mm tremors
- arrythmias
- inhibit uterine contractions at end of gestation
- Possible hypokalemia
- Effect: relieves bronchospasm/bronchoconstriction
- CI: not for prego, IM/SQ can be painful
Clenbuterol
COD: MOA: AE: Effect: CI:
- COD: bronchiole dilator
- MOA: Beta 2 agonist (longer half life than other b agonists, better oral absorption than other beta ag. in horses)
- may inhib. rls of inflamm. mdtrs from mast cells
- stimulates dvlpmt of more mm and less fat - AE: tachycardia
- tremors
- arrhythmias
- adverse effect on cardiac fxn in horses w/chronic use
-Effect: relieves animals w/reversible bronchoconstriction - CI: potential for human and livestock show abuse
NEVER for animals intended for food
Hydrocodone
COD:
MOA:
AE:
CI:
- COD: antitussive, analgesic
- MOA: MU opioid, Kappa agonist- inhib. rls of neurotrans involved w/pain, analgesic
- AE: sedation, constipation, bradycardia, resp. depression , paradoxical excitement
- CI: not in ptnts sens to opiods. oral use prep involves atropine so not with animals that aren’t supposed to have atropine
Most Common antineoplastic Adverse Effects:
Bone Marrow Suppression
GI issues
Antineoplastic Drugs:
- List them
- Cisplatin - Methotrexate - Toceranib
- Cyclophosphamide - Doxorubicin
- Lomustine - L-Asparaginase
- 5-FU - Vincristine
- Cytarabine - Piroxicam
Cisplatin
COD: MOA: AE: Effect: CI: Legal:
- COD: Antineoplastic
- MOA: alkylates DNA forming a reactive carbonium ion and cross links DNA
- AE: NEPHROTOXIC, K wasting, Mg depleting
- cats: PULMONARY TOXICOSIS (DON”T USE: SPLATS CATS)
- dogs: vomit, thrombocytopenia - Effect: Cell cycle independant (all alkylating agents),alkylating agent - treats solid tumors
- CI: NOT IN CATS
- Legal: NOT for animals intended for food
Cyclophosphamide
COD: MOA: AE: CI: Legal:
- COD: Antineoplastic; in nitrogen mustard group
- MOA: alkylating N7 of guanine base of DNA; requires metabolization via P450 to become active
- AE: bone marrow tox, V/D, HEMORRHAGIC CYSTITIS, hair loss in dogs
- CI:bone marrow and immuno suppressive, caution for those at risk of infection, teratogenic, embryotoxic (not for prego)
- Legal: NOT for animals intended for food
- NOTE: - Effect: Cell cycle independant (all alkylating agents),
Lomustine
COD: MOA: AE: Effect: CI: Legal:
- COD: Antineoplastic
- MOA: alkylates O6 on guanine and causes interstrand links
- AE: myelosuppression, thrombocytopenia, pulmonary fibrosis, hepatotoxicity, cats: neutropenia
- Effect: nitrosureas alkylating agent (for CNS, mast cell tumors and lymphoma)
- CI: bone marrow risk in small animals
- Legal: NOT for animals intended for food
5-FU
COD: MOA: AE: Effect: CI: Legal: Phase:
- COD: Antineoplastic
- MOA: inhib. nucleic acid synth
- AE: leukopenia, thrombocytopenia, CNS tox.
- Effect: pyrimidine antimetabolite; dogs
- CI: not for cats
- Legal: NOT for animals intended for food
- Phase: S phase
Cytarabine
COD: MOA: AE: Effect: CI: Legal:
- COD: Antineoplastic
- MOA: inhib DNA synth
- AE: bone marrow suppression, granulocytopenia, nausea, vomit
- Effect: Pyrimidine antimetabolite, used for lymphoma and leukemia
- CI: caution if given marrow suppression drugs
- Legal: NOT for animals intended for food
Methotrexate
COD: MOA: AE: Effect: CI: Legal: Phase:
- COD: Antineoplastic
- MOA: inhib. dihydrofolate reductase (nec. for purine synth from folic acid)
- AE: anorexia, nausea, myelosuppression, vomit, heptotox.
- Effect: folic acid antimetabolite
- Legal: NOT for animals intended for food
- Phase: S Phase
Doxirubicin
COD MOA AE Effect CI Legal Phase
- COD: Antineoplastic
- MOA: inhib. topoisomerase II causing DNA dmg and stops transcription
- AE: CARDIOTOXICITY, bone marrow tox, alopecia, anorexia, vomit, diarrhea, hypersens. rxns (NECROSIS IF OUTSIDE OF VEINS)
- Effect: natural antibiotic, anticancer agent; used for lymphoma, osteosarcoma, carcinoma, sarcoma
- CI: not w/cardiomyopathy, monitor CBS, caution MDR (prone to tox)
- Legal: NOT for animals intended for food
- Phase: S phase
L-Asparaginase
COD: MOA: AE: Effect: CI: Legal: Phase:
- COD: antineoplastic
- MOA: destroys asparagine (needed for DNA/RNA synth)
- AE: hypersens, heptotox, pancreatitis, hyperglycemia
- Effect: natural enzyme
- Legal: NOT for animals intended for food
- G1 Phase
Vincristine
COD: MOA: AE: Effect: CI: Legal: Phase
- COD: Antineoplastic
- MOA: blocks polymerization of tubulin (arrests microtubules needed for metaphase)
- AE: peripheral neurophathy, constipation, irritating to tissues (NECROSIS IF OUTSIDE OF VEINS), less myelosuppressive than other drugs
- Effect: natural Vinca Alkaloid
- CI: flush area w/fluids after admin, dogs w/ABCB-1 mutation can tox.
- Legal: NOT for animals intended for food
- M phase
Piroxicam
COD: MOA: AE: Effect: CI: Legal:
- COD: Antineoplastic
- MOA: COX inhibitor
- AE: GI tox, renal tox, toxic epidermal necrolysis
- Effect: COX inhib, transitional and squamous cell carcinoma
- CI: dogs; increased risk of ulcers, not for prego or renal dz
- Legal: NOT for animals intended for food
Sedatives
Acepromazine, Diazepam, Midazolam, Detomidine, Dexmedetomidine, Romifidine, Xylazine
Reversals
Atipamezole, Flumazenil, Naloxone, Naltrexone, Tolazoline, Yohimbine
Diazepam: Theraputic goal: MOA: AE: CI:
Theraputic goal: Sedation, tranquilization, inc appetite and muscle relaxation, reduce seizures, anxiety, and inappropriate behavior.
MOA: Potentiate GABA receptors in CNS.
AE: IM/SQ pain and irritation, IV phlebitis, sedation. Dogs: ataxia, polyphagia, excitement, agitation. Cats: idiopathic fatal hepatic necrosis. Chronic: withdrawal syndrome.
CI: Impaired liver function.
Reversals that are opiate antagonists.
Which drugs would they compete against?
Reversals: Naloxone, Naltrexone.
Opiate agonists: morphine, oxymorphone, butorphanol, hydromorphone, and other opioids
Reversals that are GABA potentiator antagonists.
Which drugs would they compete against?
Reversals: Flumazenil.
GABA potentiators/Benzodiazepines: Diazepam, lorazepam, midazolam.
Romifidine: Theraputic goal: MOA: AE: CI:
Theraputic goal: Sedation.
MOA: Alpha2 agonist.
AE: Dec sympathetic, initial hypertension followed by hypotension, paradoxical excitement, hyperglycemia/diuresis, sinoatrial block, AV block, sinus arrhythmia. Horse: ataxia, head droop, sweat. High dose: facial edema.
CI: older with cardiac disease.
Dopamine antagonists
Acepromazine, Chlorpromazine
Acepromazine: Theraputic goal, MOA, AE, CI. Effect:
Theraputic goal: Sedation, antiemetic.
MOA: Centrally acting dopamine antagonist, antimuscarinic, alpha receptor antagonist.
AE: VASODILATION/HYPOTENSION, Sedation, ataxia
Horses- persistent penile prolapse (PARAPHIMOSIS). Brachyceph- inc vagal tone.
CI: Dystonia, history of extrapyramidal effects.
Effect: antiemesis, mm relaxation, sedation/tranqu.
Chlorpromazine: Theraputic goal: MOA: AE: CI: Effect:
Therapeutic goal: Tranquilizer.
MOA: Centrally acting dopamine (D2) antagonist.
AE: Sedation, VASODILATION (HYPOTENSION), anticholinergic. Horse: violent reactions, penile prolapse (paraphimosis), EXTRAPYRIMDAL EFFECTS (looks excited but is mm related)
CI: Horses. caution in seizures and hypotensive prone animals
Effect: anti-emetic, mm. relaxation, sedation/tranqu
Diazepam: Theraputic goal: MOA: AE: CI:
Theraputic goal: Sedation, tranquilization, inc appetite and muscle relaxation, reduce seizures, anxiety, and inappropriate behavior.
MOA: Potentiate GABA receptors in CNS.
AE: IM/SQ pain and irritation, IV phlebitis, sedation. Dogs: ataxia, polyphagia, excitement, agitation. Cats: idiopathic fatal hepatic necrosis. Chronic: withdrawal syndrome.
CI: Impaired liver function.
Gabapentin
COD: MOA: AE: Effect: CI:
- COD: anticonvulsant
- MOA: analog of GABA (NOT agonist), may block Ca dependent channels
- AE: sedation, ataxia, oral solution has xylitol (toxic) produces hypoglycemia and liver injury w/high doses
- Effect: anticonvulsant, analgesic - tx neuropathic pain that won’t respond to NSAIDS
- CI: antacids decrease oral absorption
Levetiracetam
COD:
MOA:
AE:
CI:
- COD: anticonvulsants
- MOA: inhib. burst firing of neurons w/out affecting normal neuronal excitement
- AE: weakness, lethargy, dizziness, decrease appetite
- CI: phenobarb. can enhance clearance
Phenobarbital
COD: MOA: AE: CI: Note:
- COD: anticonvulsant
- MOA: stabilizes neuron by increased CL conductance due to GABA mediated channels
- AE: dose related: polyphagia, sedation, ataxia, lethargy, hepatotox, neutropenia, anemia, thrombocytopenia, superficial necrolytic derm. in dogs
- CI: caution w/liver issues, induces its own metabolism, prego animals can seizure
- NOTE: can measure the levels in the animal and adjust your dosage accordingly. ENDUCES IT”S OWN METABOLISM
Phenytoin
COD: MOA: AE: Effect: CI:
- COD: Anticonvulsant
- MOA: depress nn conduction via block Na channels, Class 1 cardiac antiarrythmic, increases threshold and decreases conduction
- AE: sedation, gingival hyperplasia, skin rxn, CNS tox,
- Horses: recumbency, excitement at high doses - Effect: anticonvulsant, antiarrythmic - used for ventricular arrythmia, myotonia, rhabdomyolysis, hyperkalemic paresis and stringhalt
- CI: not for prego, P450 inducer
Potassium Bromide
COD:
MOA:
AE:
CI:
- COD: anticonvulsant
- MOA: changes Cl conductance
- AE: PU/PD, polyphagia, ataxia, sedation, GI CNS signs, nausea, cat bronchitis
- CI: not prego, P450 inducer
Zonisamide
COD:
MOA:
AE:
CI:
- COD: anticonvulsant
- MOA: potentiates GABA stabilizing membranes w/changes in Na & Cl channels
- AE: none at clinical doses (lethargy, ataxia, vomit w/overdose)
- CI: caution w/ allergies to sulfonamides
Lorazepam: Theraputic goal: MOA: AE: CI:
Theraputic goal: Tranquilizer.
MOA: Potentiate GABA receptors in CNS.
AE: Sedation, polyphagia, paradoxical excitement.
CI: None.
Midazolam: Theraputic goal: MOA: AE: CI:
Theraputic goal: Sedation.
MOA: Potentiate GABA receptors in CNS.
AE: Paradoxical excitement, chronic leads to withdrawl syndrome, IV can cause serious cardiorespiratory depression.
CI: IV, concurrent with opiates.
Detomidine: Theraputic goal: MOA: AE: CI:
Theraputic goal: Sedation.
MOA: Alpha2 agonist.
AE: Sedation ataxia, sweating, bradycardia, hyperglycemia/diuresis. High dose- cardiac depression, AV block, hypotension. Horses: hyperresponsiveness.
CI: can be absorbed through human skin.
Dexmedetomidine: Theraputic goal: MOA: AE: CI:
Theraputic goal: Sedation.
MOA: Alpha2 agonist.
AE: Dec sympathetic, initial hypertension followed by hypotension, paradoxical excitement, hyperglycemia/diuresis. Sm: vomiting.
CI: Older with cardiac disease. Can be absorbed through human skin.
Yohimbine: Theraputic goal: MOA: AE: CI:
Theraputic goal: Reversal.
MOA: Alpha2 antagonist.
AE: High dose- tremors and seizures.
CI: None.
Xylazine: Theraputic goal: MOA: AE: CI:
Theraputic goal: Sedation.
MOA: Alpha2 agonist.
AE: Dec sympathetic, initial hypertension followed by hypotension, paradoxical excitement, hyperglycemia/diuresis, AV block, sinus arrhythmia. Sm: vomiting.
CI: Older with cardiac disease. Can be absorbed through human skin.
Atipamezole: Theraputic goal: MOA: AE: CI:
Theraputic goal: Reversal.
MOA: Alpha2 antagonist.
AE: Initial excitement, transient decrease in blood pressure.
CI: None.
Flumazenil: Theraputic goal: MOA: AE: CI:
Theraputic goal: Reversal.
MOA: Benzodiazepine (GABA potentiator) receptor antagonist.
AE: None.
CI: None.
Naloxone: Theraputic goal: MOA: AE: CI:
Theraputic goal: Reversal.
MOA: Opiate antagonist.
AE: Tachycardia, hypertension, excitement, pain, cardiac arrhythmias.
CI: Animals in pain.
Naltrexone: Theraputic goal: MOA: AE: CI:
Theraputic goal: Reversal.
MOA: Opiate antagonist.
AE: None.
CI: Animals in pain.
How to calculate Replacement fluid
- Maintenance Fluid
- 24 hr needs
Kg in weight X % dehydrated
(gives you L, so convert to ml if needed)
- M:
30 x kg wt + 70
(gives you ml) - 24 hr:
Add Replacement + Maintenance + Loss
Tolazoline: Theraputic goal: MOA: AE: CI:
Theraputic goal: Reversal.
MOA: Alpha2 antagonist.
AE: Hypertension, tachycardia, peripheral vasodilation.
CI: Animals in stress, debilitation, cardiac disease, sympathetic blockage, hypovolemia, shock.
Toceranib Therapeutic goal MOA AE CI
TG: Antineoplastic
MOA: inhibits receptor tyrosine kinase
AE: GI problems, anorexia, lameness, weight loss, blood in feces
CI: Prego