Test 1 MOAs Flashcards
Acepromazine MOA
Inhibits central dopaminergic and is antimuscarinic and blocks norepinephring at adrenergic receptors (alpha receptors). Sedation and vasodialation.
Acetaminophen MOA
Analgesic: Inhibits centrally mediated pain transmission by inhibition of COX 3, inhibit prostaglandins in tissues low in arachidonic acid. Site of action is peroxidase enzyme on prostaglandin H2 synthase. Stimulate inhibitory pain pathwasy mediated by serotonin (5HT3)
Altrenogest MOA
Synthetic progestin thus progesterone agonist. Suppresses estrus, predictable estrous activity once discontinued. Useful to induce syncronized normal cycle of estrous.
Apomorphine MOA
Emetic; potent lipophilic agent that crosses the blood brain barrier to stimulate dopamine receptors in the vomiting center. Not absorbed orally due to first pass effect.
Aspirin MOA
NSAID: Binds irreversibly to COX enzyme in tissues to inhibits synthesis of prostaglandins. Inhibition of NF kappa-B.
Azathioprine MOA
Inhibits T-cell lymphocyte function specifically purine metabolism
Benzocaine MOA
Inhibits Na channels on neurons thus inhibiting depolarization and conduction of nerve impulses.
Betamethasone MOA
Corticosteroid (no glucocorticoid effects) that inhibits inflammatory cells, suppresses expression of inflammatory mediators. Anti-inflammatory and immunosuppressive.
Budesonide MOA
Corticosteroid. High glucocorticoid and weak mineralocorticoid
Bupivacain MOA
Inhibits Na channels on neurons thus inhibiting depolarization and conduction of nerve impulses. Binds to prostaglandin E2 receptors to inhibit production of prostaglandins thus reduce fever, inflammation, and hyperalgesia
Carprofen MOA
NSAID: inhibits COX, relatively COX 1 sparing
Chlorambucil MOA
Cytotoxic agent: nitrogen mustard
Ciclesonide MOA
Affinity for glucocorticoid receptor that has anti-inflammatory activity
Cisapride MOA
Increase GI motility: Agonist for 5-hydroxytryptamine (5-HT4) recetors on myenteric neurons, antagonist for 5-HT3 receptor, thus enhanses the release of acetylcholine at the myenteric plexus thereby increasing motility of the stomach, SI, and colon.
Cloprostenol MOA
Synthetic prostaglandin (PGF2-alpha) provides PGF2 alpha effects. Direct luteolytic action on CL. In non-cycling cows induces etrus in 2-5 days. Terminates pregnancy. Resolution of pyometra, mummified fetus, or luteal cyst.
Cyclophosphamide MOA
Cytotoxic and anticancer agent. Nitrogen mustards that alkylate various macromolecules (guanine of DNA), toxic to rapidly proliferating cells
Cyclosporine MOA
Binds to receptor on calcineurin and inhibits the t cell receptor activated signal transduction pathway. Blocks cytokines (IL 2) and block proliferation of activated T lymphocytes
Cyproheptadine MOA
Antiserotonin properties that alter serotonin activity in appetite center.
Deracoxib MOA
NSAID: inhibits COX, relatively COX 1 sparing
Desoxycorticosterone pivalate MOA
Mineralocorticoid without glucocorticoid activity, mimics the effects of aldosterone by retaining Na.
Dexamethasone MOA
Corticosteroid that inhibits inflammatory cells, suppresses expression of inflammatory mediators. Anti-inflammatory and immunosuppressive. Glucocorticoid effects.
Diazepam MOA
Potentiation of GABA-receptor-mediated effects in CNS.
Diclofenac MOA
NSAID: inhibits COX thus inhibiting prostaglanding formation
Dinoprost MOA
Synthetic prostaglandin (PGF2-alpha) provides PGF2 alpha effects. Direct luteolytic action on CL. In non-cycling cows induces etrus in 2-5 days. Terminates pregnancy. Resolution of pyometra, mummified fetus, or luteal cyst.