Test 1 Ch.15 Sedatives, Analgesics, and Paralytics Flashcards

1
Q

Sedatives are used to reduce (4)

A

anxiety, agitation, promote sleep and for anterograde amnesia

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2
Q

Analgesics are used to

A

lessen pain

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3
Q

Paralytics are used to facilitate……
And prevent _________________ and ensure the stability of _____________ airways

A

invasive procedures (e.g surgery, ETT intubation)
movement;
artificial;

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4
Q

What are the different levels of sedation

A
  • Minimal sedation
  • Moderate sedation (Conscious sedation)
  • Deep sedation
  • Anesthesia
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5
Q

With minimal sedation pt’s can respond to verbal commands, although

A

cognitive function may be impaired. Ventilatory and cardiovascular functions are unaffected

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6
Q

Moderate sedation (conscious sedation) the pt can perform purposeful response after repeated or

A

painful stimulation. Spontaneous ventilation is adequate, and cardiovascular function is maintained

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7
Q

Deep sedation, the pt is not easily

A

aroused but can respond to painful stimulation. Spontaneous ventilation and maintenance of pt airway patent airway may be inadequate. Cardiovascular function is usually maintained

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8
Q

In Anesthesia, this level involves general anesthesia, spinal, or major regional anesthesia. Pt cannot be

A

aroused, even by painful stimulation. Ventilatory assistance is typically required. Cardiovascular function may be impaired

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9
Q

Ramsay Sedation Scale (RSS) is used to

A

assess the level of sedation in adults in children

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10
Q

______________________ have been the drugs of choice for tx of __________ in critical care

A

Benzodiazepines;
anxiety

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11
Q

What are the drugs in the Benzodiazepines group?

A
  • Diazepam
  • Midazolam
  • Lorazepam
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12
Q

Benzos are relatively low cost and the ability of these drugs produce: (5)

A
  • anxiolytic
  • hypnotic
  • muscle relaxtion
  • anticonvulsant (anti- seziure)
  • anterograde amnesic effects
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13
Q

______________________ is an a2- adrenorecptor agoinst used for….

A

Dexmedetomidine (Precedex);
short-term sedation in the ICU

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14
Q

Dexmedetomidine (Precedex) has no effect on…
and is used alot in

A

pt’s breathing;
weaning

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15
Q

Neuroleptics are used to treat pt’s demonstrating evidence of

A

extreme agitation and delirium

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16
Q

What is the generic name for neuroleptics

A

Haloperidol

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17
Q

Haloperidol (Haldol) is used to treat

A

delirium in pts in ICU

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18
Q

Anesthetic agents such as __________ is an IV, generic anesthetic agent that possesses sedative, amnesic, and hypnotic properties at low doses, although it has no

A

Propofol (Diprivan);
analgesic properties

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19
Q

Opiodes (opiates) are used to

A

relieve pain

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20
Q

generic names for opiodes

A
  • Morphine
  • Fentanyl
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21
Q

What drug is a naturally occurring opioid agonist?

A

Morphine sulfate

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22
Q

What are opioids reversed with?

A

Naloxone (Narcan)

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23
Q

Morphine is a potent opioid analgesic that is the preferred agent for intermittent therapy b/c of its…..

A

longer duration of action

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24
Q

Fentanyl citrate (Sublimaze) is a synthetic opioid that is approximately

A

100 to 150 times more potent than morphine

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25
Which opioid has a longer half-life and can accumulate in the peripheral tissues after prolong infusion?
Fentanyl
26
Propofol has a _______ onset and _____ duration of sedation once it is discontinued
rapid; short
27
The rapid awakening from propofol allows interruption of the infusion for
neurological assessment
28
Reversal of the effects of benzos can be accomplished w/
flumazenil (Romazicon)
29
What are the 2 classes of NMBAs available for paralyzing pts on MV?
- Depolarizing agents - Nondepolarizing agents
30
What is the name of the 1 depolarizing drug for NMBA?
Succinylcholine
31
Succinylcholine chloride (Anectine) is short acting 5 to 10 mins depolarizing muscle relaxant that has an onset of action of approximately
60 seconds
32
What is the brand name for Diazepam?
Valium
33
Midazolam
Versed
34
Lorazepam
Ativan
35
Haloperidol
Haldol
36
Propofol
Diprivan
37
Morphine Sulfate
Generic only
38
Fentanyl Citrate
Sublimaze
39
Dexmedetomidine
Precedex
40
Pancuronium
Pavulon
41
Succinylcholine chloride
Anectine
42
Hydromorphone
Dilaudid
43
What are some sedatives (8)
- Diazepam - Madazolam - Lorazepam - Chloriduazepoxide - Alprazolam - Triazolam - Flurazepam - Dexmedetomidine (precedex)
44
Brand name for Chloriduazepoxide
Librium
45
Alprazolam
Xanax
46
Triazolam
Halcion
47
Flurazepam
Daimane
48
What are some examples of nondepolarizing agents (5) (-um)
- Pancuronium - Vecuronium - Atracurium besylate - Cisatracurium - Rocuronium
49
Vecuronium
Norcuron
50
Atracurium besylate
Tracrium
51
Cisatracurium
Nimbex
52
Rocuronium
Zemuron
53
Fentanyl has minimum effects on the
cardiovascular system
54
Which drug is an acceptable substitute for morphine?
Hydromorphone (Dilaudid)
55
Which non-depolarizing agent was one of the first NMBAs used for prolonged paralysis of pts on MV in ICU?
Pancuronium (Pavulon)
56
What are the most common reasons for using NMBAs in pts on MV? (5)
- pt-ventilator asynchrony that cannot be corrected with vent settings - Facilitation of less conventional MV strategies (i.e inverse I/E ratios, high-frequency ventilation, permissive hypercapnia) - Facilitation of intubation, ensuring the stability of the airway during transport, or repositioning - Dynamic hyperinflation that cannot be corrected - Reduction of oxygen consumption and carbon dioxide production
57
Neuromuscular blocking agents are used for
paraylzing pts on MV in ICU
58
How do you monitor neuromuscular blockade?
visual, tactile, and electrical assessment of the pt's muscle tone
59
What is a common method used to assess the pt's depth of paralysis?
An electrical technique called **train-of-four** (TOF) monitoring
60
Which nondepolarizing NMBA was an effective means of producing prolonged paralysis in pts with renal insufficiency?
Vecuronium bromide (Norcuron)
61
Fentanyl is preferred for pts w/
hemodynamic instability and renal insufficiency
62
What are some Sedatives (Benzos)
- Diazepam (Valium) - Midazolam (Versed) - Lorazepam (Antivan)
63
What are some Neuroleptics?
Haloperidol (Haldol)
64
What are some Anesthetics?
Propofol (Diprivan)
65
What are some Opioids (Narcotic Analgesics)
- Morphine Sulfate - Fentanyl Citrate (Sublimaze) - Hydromorphine (Dilaudid)
66
What are some hemodynamic effects of propofol?
Reduced blood pressure, bradycardia, reduces cerebral blood flow and ICP
67
Continual use of lorazepam has been associated w/ serval side effects including: (3)
- Lactic acidosis - hypersomolar coma - a reversible neurotoxicity
68
Fentanyl does not cause ______________ release as does morphine
Histamine
69
The severity of opioid side effects depends on what three things?
- Dosage administered - Extend of pt's illness - Integrity of organ function
70
Diazepam elimination can be decreased in what type of pts?
Older pts, neonates and pts w/ compromised hepatic and renal functions
71
Adverse effects of propofol administration (3)
- Hypotension, dysrhythmias - Elevation of pancreatic enzymes - Bradycardia
72
What 2 drugs should be used for **rapid sedation** of acutely agitated pts
- Midazolam - Diazepam
73
What is the drug of choice for **sedating** mechanically ventilated pts in the ICU for longer than 24 hours?
Lorazepam (Ativan)
74
What are some of the most common side effects of flumazenil
- Dizziness - Panic attack - Cardiac ischemia May lead to seizures in pts receiving long term administration
75
Depolarizing agents resemble _______________ in their chemical structure
Acetylcholine