Test 1 Flashcards
Who sequenced the HGP?
The government and a private corporation together. (The NIH and the Celera Corp)
How much did the HGP cost?
3 billion dollars and said to have an economic impact of $796 million. THIS WAS SUPER CHEAP
When was the HGP completed?
Completed in 2003
Who owns the HGP?
The people! Payed for by our taxes.
What were the goals of the HGP? (7)
1. Sequence of >95% of the nucleotides 2. Identify all the genes 3. Produce a physical and linkage map 4. Reduce cost of DNA sequencing technology 5. Develop genome-scale functional analyses (e.g. microarrays) 6. Describe genetic variation among human populations 7. Set up Ethical, Legal and Social Implications program
Why did we even do the HGP?
To help medicine, comparative genomics, population genetics
What did the HGP actually tell us?
–25k genes –1.5% of genome encodes proteins –96% similarity with chimpanzee genome * –0.17% of the human genome varies between individuals -More than 3000 genes linked to disease
Heritability
look at def on ppt example
What are three examples of discrete traits?
Eye color, tongue curling, earlobe attachment
What are three examples of continuous traits?
Obesity, diabetes, vision *Most traits continuous
What is a polygenic trait?
Trait influenced by many genes
What is continuous variation a result of? Environment or genes?
A combination of both
Vp=
Total PHENOTYPIC variance
Vg=
Varianve due to genetic factors
Ve=
Variance due to difference in enviromental influence
