Test 1 Flashcards
Fried rule
Applies to a child younger than 2
Child’s dose (1-2yr)=[(child’s age in months)/150] x average adult dose
Young Rule
Applies to children 1-12 years
Child’s dose (1-12yr)=[(child’s age in years)/child’s age + 12] x average adult dose
Clark rule
Infants under 1 year
Child’s dose = (weight of child (lb)/150) x average adult dose
Acquired immunodeficiency syndrome (AIDS)
Collection of Opportunistic infections and cancers that occurs when the immune system is severely depressed by a decrease in the the number of functioning helper T cells; caused by infection with human immunodeficiency virus (HIV)
AIDS related complex (ARC)
Collection of less serious Opportunistic infections with HIV infection; The Decrease in the number of helper, T cells is less severe than in fully developed AIDS
CCR5 coreceptor antagonist
A drug that blocks the receptor site on the T cell membrane that the HIV virus needs to interact with in order to enter the cell
Cytomegalovirus (CMV)
DNA virus that accounts for many respiratory ophthalmic and liver infections
Fusion inhibitor
A drug that prevents the fusion of the HIV-1virus with the human cellular membrane, preventing it from entering the cell
Helper T cell
Human lymphocyte that helps to initiate human immune reactions in response to tissue invasion
Hepatitis B
A serious to potentially fatal, viral infection of the liver, transmitted by bodily fluids
Hepatitis C
A usually mild, viral infection of the liver that can progress to chronic inflammation; most often seen hepatitis after blood transfusions
Herpes
DNA virus that accounts for many diseases, including shingles, cold, sores, genital, herpes, and encephalitis
Human immunodeficiency virus (HIV)
Retro virus that attacks helper T cells, leading to a decrease in immune function, and AIDS or ARC
Influenza A
RNA virus that invades tissues of the respiratory tract, causing the signs and symptoms of the common cold or flu
Integrase inhibitor
A drug that inhibits the activity of the virus, specific enzyme, integrase, an encoded enzyme needed for viral replication; blocking this enzyme prevents the formation of the HIV-1 pro virus
Interferon
Tissue hormone that is released in response to viral invasion; blocks viral replication
Non-nucleoside reverse transcriptase inhibitors
Drugs that bind to sites on the reverse transcriptase within the cell cytoplasm, preventing RNA and DNA dependent DNA polymerase activities, needed to carry out, viral DNA synthesis; prevents the transfer of information that allows the virus to replicate and survive
Nucleoside reverse transcriptase inhibitors
Drugs that prevent the growth of the viral DNA chain, preventing it from inserting into the host, DNA, so viral replication cannot occur
Protease inhibitors
Drugs that block, the activity of the enzyme, protease, and HIV; protease is essential for the maturation of infectious virus, and it’s absence leads to the formation of an immature and non-infective HIV particle
Virus
Particle of DNA or RNA, surrounded by a protein coat that survives by invading a cell to alter its functioning
Active immunity
The formation of antibodies secondary to exposure to a specific antigen; leads to the formation of plasma, cells, antibodies, and memory cells to immediately produce antibodies, if exposed to that antigen in the future; imparts lifelong immunity
Anti-toxins
Immune sera that contain antibodies to specific toxins, produced by invaders; may prevent the toxin from adhering to body, tissues, and causing disease
Antivenins 
Immune sera that contain antibodies to specific venins , produced by poisonous snakes or spiders; may prevent venom from causing cell death
Biological
Vaccines,immune sera, and anti-toxins that are used to stimulate the production of antibodies to provide performed antibodies to facilitate an immune reaction, or to react specifically with the toxins produced by an invading pathogen
Immune sera
Preformed antibodies found in immunoglobulin from animals or humans who have had a specific disease and developed antibodies to it
Immunization
The process of stimulating active immunity by exposing the body to weekend, or less toxic proteins associated with specific disease causing organisms; the goal is to stimulate immunity without causing the full course of a disease
Passive immunity
The injection of performed antibodies into a host at high risk for exposure to a specific disease; immunity is limited by the amount of circulating antibodies
Serum sickness
Reaction of a host to injected antibodies or foreign sera; host cells, make antibodies to the foreign proteins and a massive immune reaction can occur
Apnea
Temporary cessation of breathing
Bronchophony
Abnormal increase in clarity of transmitted voice sounds heard, when osculating belongs
Bronchoscopy
Direct examination of the larynx trachea and bronchi using endoscope
Cilia
Short fine hairs that provide a constant whipping motion that serves to propel mucus and foreign substances away from the lung toward the larynx
Compliance
Measure of the force required to expand or inflate the lungs
Crackles
Non-musical discontinuous popping sounds during inspiration caused by delayed reopening of the airways heard on chest auscultation 
Dyspnea
Subjective experience that describes an uncomfortable or painful, breathing sensation when either at rest, or while walking or climbing stairs; also commonly referred to as shortness of breath
Egophony
Abnormal change in tone of voice that is heard when auscultating the lungs
Fremitus
Vibrations of speech felt as tremors of the chest wall during palpitation
Hemoptysis
Expectoration of blood from the respiratory tract
Hypoxemia
Decrease in arterial oxygen tension in the blood
Hypoxia
Decrease in oxygen supply to the tissues and cells
Obstructive sleep apnea
Temporary absence of breathing during sleep, secondary to transient upper airway obstruction
Orthopnea
Shortness of breath, when lying flat; relieved by sitting or standing
Oxygen saturation
Percentage of hemoglobin that is bound to oxygen
Physiologic dead space
Portion of the tracheobronchial tree that does not participate in gas exchange
Pulmonary diffusion
Exchange of gas molecules (Oxygen and carbon dioxide ) From areas of high concentration to areas of low concentration 
Pulmonary perfusion
Blood flow through the pulmonary vasculature
Respiration
Gas exchange between atmospheric air, and the blood, and between the blood and cells of the body
Rhonchi
Deep, low pitch snoring sounds associated with partial airway, obstruction, heard on chest auscultation
Strider
Continuous, high-pitched, musical sound heard on inspiration, best heard over the neck; may be heard, without use of a stethoscope, secondary to upper airway obstruction
Tachypnea
Abnormally, rapid, respirations
Tidal volume
Volume of air inspired an expired with each breath during normal breathing
Ventilation
Movement of air in and out of the airways
Wheezes
Continuous musical sounds associated with airway narrowing or partial obstruction
Whispered pectoriloquy
Whispered sound heard loudly, and clearly upon thoracic auscultation
Acute lung injury
An umbrella term for hypoxemic respiratory failure; equivalent to mild acute respiratory distress syndrome (ARDS)
Acute respiratory distress syndrome (ARDS)
Nonspecific pulmonary response to a variety of pulmonary and non-pulmonary insults to the lung; characterized by interstitial infiltrates, alveolar hemorrhage, atelectasis, refractory hypoxemia, and with the exception of some patients with coronavirus disease, and ARDS, decreased compliance
Airway pressure release, ventilation (APRV)
Mode of mechanical ventilation that allows unrestricted, spontaneous breaths throughout the ventilatory cycle; on inspiration, the patient receives a preset, level of continuous positive, airway, pressure, and pressure is periodically released to aid expiration
Aspiration
Inhalation of either oralpharyngeal or gastric contents into the lower airways
Atelectasis
Collapse or airless condition of the alveoli caused by hypoventilation, obstruction to the airways, or compression
Bilevel, positive airway pressure (BiPAP)
Non-invasive spontaneous breath mode of mechanical ventilation that allows for the separate control of inspiratory and expiratory pressures; given via a mask
Central cyanosis
Bluish discoloration of the skin, or mucous membrane’s due to hemoglobin, caring, reduced amounts of oxygen
Chest drainage system
The use of a chest tube and closed drainage system to reexpand the lungs and remove excess air, fluid, or blood
Consolidation
Lung tissue that has become more solid in nature due to the collapse of alveoli are infectious process (Pneumonia )
Continuous mandatory (Volume or pressure ) Ventilation (CMV)
Also referred to as assist control (A/C) Ventilation; mode of mechanical ventilation, in which the patient’s breathing pattern may trigger the ventilator to deliver a preset tidal, volume or step pressure; in the absence of spontaneous breathing, the machine delivers a controlled breath at a preset, minimum rate, and tidal volume or set pressure 
Continuous positive airway pressure (CPAP)
Positive pressure applied throughout the respiratory cycle to a spontaneous breathing patient to promote alveolar and airway stability and increase functional residual capacity; may be given with endotracheal, or tracheostomy tube or by mask
Cor pulmonale
Heart of the lungs; enlargement of the right ventricle from hypertrophy or dilation as a secondary response to disorders that affect the lungs
Empyema
Accumulation of purulent material in the plural space
Endotracheal intubation
Insertion of a breathing tube through the nose or mouth into the trachea
Hemoptysis
The coughing up of blood from the lower respiratory tract
Hemothorax
Partial or complete collapse of the lung due to blood accumulating in the pleural space; may occur after surgery our trauma
Hypoxemia
Decrease in oxygen tension in the arterial blood
Hypoxia
Decrease in oxygen supply to the tissues and cells
Incentive spirometry
Method of deep breathing that provides visual feedback to help the patient inhale deeply, and slowly and achieve maximum long inflation
Intermittent mandatory (Volume or pressure ) Ventilation (IMV)
Mode of mechanical ventilation that provides a combination of mechanically assisted breaths at a preset volume of pressure and rate and spontaneous breaths
Induration
An abnormally, hard, legion or reaction, as in a positive tuberculosis skin test
Mechanical ventilator
A positive or negative pressure, breathing device that supports ventilation and oxygenation
Orthopnea
Shortness of breath, when reclining in or in the supine position
Plural effusion
Abnormal accumulation of fluid in the pleural space
Plural Friction rub
Localized grating or creaking sound caused by the rubbing together of inflamed, parietal and visceral pleura
Pleural space
The area between the parietal and visceral pleura a potential space
Pneumothorax
Partial or complete collapse of the lung due to a positive pressure in the pleural space
Positive end expiratory pressure (PEEP)
Positive pressure maintained at the end of exhalation (Instead of a normal zero pressure) To increase functional residual capacity and open collapsed alveoli 
Pressure support ventilation (PSV)
Mode of mechanical ventilation, in which preset positive pressure is delivered with spontaneous breaths to decrease work of breathing
Proportional assist ventilation (PAV)
Mode of mechanical ventilation that provides partial ventilator support in proportion to the patient’s inspiratory effort; decreases the work of breathing
Purulent
Consisting of, containing, or discharging puss
Respiratory weaning
Process of gradual, systematic, withdrawal, a removal of ventilator, breathing tube, and oxygen
Restrictive lung disease
Disease of the lung that causes a decrease in lung volumes
Synchronized intermittent mandatory ventilation (SIMV)
Mode of mechanical ventilation, in which the ventilator allows the patient to breathe spontaneously, while providing a preset number of breaths to ensure adequate ventilation; ventilated breaths are synchronized with spontaneous breathing
Tension pneumothorax
Pneumothorax characterized by increasing positive pressure in the plural space with each breath; this is an emergency situation, and the positive pressure needs to be decompressed or released immediately
Thoracentesis
Insertion of a needle or catheter into the pleural space to remove fluid that has accumulated and decrease pressure on the lung tissue; may also be used diagnostically to identify potential causes of plural effusion
Thoracotomy
Surgical opening into the chest cavity
Tidal volume
Volume of air inspired an expired with each breath
Tracheostomy tube
Indwelling tube inserted directly into the trachea to assist with ventilation
Tracheostomy
Surgical opening into the trachea
TransBronchial.
Through the bronchial wall, as in a trans bronchial, lung biopsy
Ventilation perfusion (V./Q.)
Refers to the ratio between ventilation and perfusion in the lung; matching of ventilation to perfusion optimize gas exchange
Air trapping
Incomplete emptying of alveoli during expiration due to loss of lung tissue elasticity (emphysema), Bronchospasm (Asthma ), or airway obstruction 
Alpha1 antitrypsin deficiency
Genetic disorder resulting from deficiency of Alpha1 antitrypsin, A protective agent for the lung; increases patient’s risk for developing panacinar emphysema, even in the absence of smoking 
Asthma
A heterogeneous disease, usually characterized by chronic airway inflammation; defined by history of symptoms, such as wheeze, shortness of breath, chest tightness, and cough that vary overtime and in intensity
Bronchiectasis
Chronic irreversible dilation of the bronchi and bronchioles that results from the destruction of muscles and elastic connective tissue; dilated airways become saccular and are a medium for chronic infection
Chest Percussion 
Manually, cupping hands over the chest wall and using vibrations to mobilize secretions by mechanically dislodging viscous or adherent secretions in the lungs
Chest physiotherapy (CPT)
Therapy used to remove bronchial, secretions, improve ventilation, and increase the efficiency of the respiratory muscles; types include postural drainage, chest percussion, and vibration and breathing retraining
Chronic bronchitis
A disease of the airways defined as the presence of cough and sputum production, for at least a combined total of three months in each of two consecutive years
Chronic obstructive pulmonary disease (COPD)
Disease state characterized by airflow, limitation, that is not fully reversible; sometimes referred to as chronic airway obstruction or chronic obstructive lung disease
Desaturate
A precipitous drop in the saturation of hemoglobin with oxygen
Dry powder inhaler (DPI)
A compact, portable inspiratory flow driven inhaler that delivers dry powder medication’s into the patient’s lungs
Emphysema
A disease of the airways characterized by destruction of the walls of over descended alveoli
Flutter valve
Portable, handheld, mucus clearance device; consisting of a tube with an osculating steel ball inside; upon expiration high frequency, oscillations, facilitate mucus expectoration
Fraction of inspired oxygen (FiO2)
Concentration of oxygen delivered (1.0 Equals 100% oxygen )
Hypoxemia
Decrease in arterial oxygen tension in the blood
Hypoxia
Decrease in oxygen supply to the tissues and cells
Polycythemia
Increase in the red blood cell concentration in the blood; in COPD, the body attempts to improve oxygen, carrying capacity by producing increasing amounts of red blood cells
Postural drainage
Positioning the patient to allow drainage from all lobes of the lungs and airways
Pressurize meter dose inhaler (pMDI)
A compact, portable patient activated pressurized medication canister that provides aerosolized medication that the patient inhales into the lungs
Small volume nebulizer (SVN)
A handheld generator driven medication delivery system that provides aerosolized liquid medication that the patient inhales into the lungs
Spirometry
Pulmonary function test that measures specific lung, volumes and rates; may be measured before and after bronchodilator administration
Vibration
A type of massage given by quickly, tapping the chest with the fingertips, or alternating the fingers in a rhythmic manner, or by using a mechanical device to assist in mobilizing lung secretions
Aerobic
Bacteria that depend on oxygen for survival
Anaerobic
Bacteria that survive without oxygen, which are often seen when blood flow is cut off to an area of the body
Gram-negative
Bacteria that accept a negative stain and are frequently associated with infections of the genitourinary or gastrointestinal tract
Gram-positive
Bacteria that take a positive stain and are frequently associated with infections of the respiratory tract and soft tissues
Synergistic
Drugs that work together to increase drug effectiveness
Adrenal cortex
Outer layer of the adrenal gland; produces glucocorticosteroids and mineralocoticosteroids in response to adrenocorticotropic hormone (ATCH) Stimulation; also responds to sympathetic stimulation 
Adrenal medulla
Inner layer of the adrenal gland; a sympathetic ganglion it releases, norepinephrine, and epinephrine into circulation in response to sympathetic stimulation
Corticosteroids
Steroid, hormones, produced by adrenal cortex; includes androgens, glucocorticoids and mineralocortids
Diurnal, rhythm
Response of the hypothalamus, and then the pituitary and adrenals, to wakefulness and sleeping; normally the hypothalamus begin secretion of corticotropin releasing factor(CRF) In the evening, peeking at about midnight; adrenocortical peek responses between 6 and 9 AM; levels fall during the day until evening when the low level is picked up by the hypothalamus and CRF secretion begins again 
Glucocorticoids
Steroid hormones released from the adrenal cortex; they increase blood glucose levels, fat deposits, and protein breakdown for energy
Mineralocorticoids
Steroid hormones, released by the adrenal cortex; they cause sodium and water retention and potassium excretion
Alveoli
The respiratory sac the smallest unit of the lungs where gas exchange occurs
Asthma
Disorder characterized by recurrent and reversible episodes of bronchospasm (Brachial muscle spasms leading to narrowed or obstructed airways )
Atelectasis
Collapse of once expanded Alveoli